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Microstructural and microperimetric comparison of internal limiting membrane peeling and insertion in large idiopathic macular hole

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收录情况： ◇ SCIE

作者：
Liu Lingzi[1,2] * ; Wang Zengyi[1,2] * ; Yu Yanping[1,2] ; Yang Xiaohan[1,2] ; Qi Biying[1,2] ; Zhang Ke[1,2] ; Liu Wu[1,2] ;
机构： [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China. [2]Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
出处：
DOI： 10.1186/s12886-023-03006-z
ISSN：

关键词： Idiopathic macular hole Pars plana vitrectomy Internal limiting membrane Optical coherence tomography Microperimeter-3

摘要：
The internal limiting membrane (ILM) insertion technique was widely used to treat large macular hole (MH) for the high closure rate. However, the prognosis of closed MH after ILM insertion compared to ILM peeling remains controversial. This study aimed to compare foveal microstructure and microperimeter in large idiopathic MH surgically closed by ILM peeling and ILM insertion.This retrospective, non-randomized, comparative study included patients with idiopathic MH (minimum diameter ≥ 650 μm) who underwent primary pars plana vitrectomy (PPV) with ILM peeling or ILM insertion. The initial closure rate was recorded. Patients with initially closed MHs were divided into two groups according to the surgery methods. The best-corrected visual acuity (BCVA), optical coherence tomography (OCT) and microperimeter-3 (MP-3) outcomes of two groups were compared at baseline, 1 and 4 months postoperatively.For idiopathic MH (minimum diameter ≥ 650 μm), ILM insertion had a significantly higher initial closure rate than ILM peeling (71.19% vs. 97.62%, P = 0.001). Among 39 patients with initially closed MHs who were on regular follow-up, twenty-one were assigned to the ILM peeling group and 18 to the ILM insertion group. Postoperative BCVA improved significantly in both groups. The final BCVA (logMAR) (0.40 vs. 0.88, P < 0.001), macular hole sensitivity (19.66 dB vs. 14.14 dB, P < 0.001), peripheral sensitivity of macular hole (24.63 dB vs. 21.95 dB, P = 0.005), and fixation stability (FS) within 2 degrees (82.42% vs. 70.57%, P = 0.031) were significantly better and external limiting membrane (ELM) defect (330.14 μm vs. 788.28 μm, P < 0.001) and ellipsoid zone (EZ) defect (746.95 μm vs. 1105.11 μm, P = 0.010) were significantly smaller in the ILM peeling group than in the ILM insertion group.For initially closed MHs (minimum diameter ≥ 650 μm), both ILM peeling and ILM insertion significantly improved the microstructure and microperimeter in the fovea. However, ILM insertion was less efficient at microstructural and functional recovery after surgery.© 2023. The Author(s).

基金：
This study was supported by National Key R&D Program of China, Grant/ Award Number: 2017YFA0104103.
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 4 区 医学
小类 | 4 区 眼科学
最新[2023]版：
大类 | 4 区 医学
小类 | 3 区 眼科学
JCR分区：
出版当年[2021]版：
Q3 OPHTHALMOLOGY
最新[2023]版：
Q3 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China. [2]Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China. [2]Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
推荐引用方式(GB/T 7714)：
Liu Lingzi,Wang Zengyi,Yu Yanping,et al.Microstructural and microperimetric comparison of internal limiting membrane peeling and insertion in large idiopathic macular hole[J].BMC OPHTHALMOLOGY.2023,23(1):274.doi:10.1186/s12886-023-03006-z.
APA：
Liu Lingzi,Wang Zengyi,Yu Yanping,Yang Xiaohan,Qi Biying...&Liu Wu.(2023).Microstructural and microperimetric comparison of internal limiting membrane peeling and insertion in large idiopathic macular hole.BMC OPHTHALMOLOGY,23,(1)
MLA：
Liu Lingzi,et al."Microstructural and microperimetric comparison of internal limiting membrane peeling and insertion in large idiopathic macular hole".BMC OPHTHALMOLOGY 23..1(2023):274

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