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Retinal organoid and gene editing for basic and translational research

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收录情况： ◇ SCIE

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机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730 China

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关键词： Pluripotent stem cells Gene editing Retinal organoid Retinal diseases Differentiation Delivery

摘要：

The rapid evolution of two technologies has greatly transformed the basic, translational, and clinical research in the mammalian retina. One is the retinal organoid (RO) technology. Various induction methods have been created or adapted to generate species-specific, disease-specific, and experimental-targeted retinal organoids (ROs). The process of generating ROs can highly mimic the in vivo retinal development, and consequently, the ROs resemble the retina in many aspects including the molecular and cellular profiles. The other technology is the gene editing, represented by the classical CRISPR-Cas9 editing and its derivatives such as prime editing, homology independent targeted integration (HITI), base editing and others. The combination of ROs and gene editing has opened up countless possibilities in the study of retinal development, pathogenesis, and therapeutics. We review recent advances in the ROs, gene editing methodologies, delivery vectors, and related topics that are particularly relevant to retinal studies.Copyright © 2023 Elsevier Ltd. All rights reserved.

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出版当年[2022]版：

大类 | 3 区心理学

小类 | 3 区神经科学 3 区眼科学 3 区心理学

最新[2023]版：

大类 | 4 区心理学

小类 | 4 区神经科学 4 区眼科学 4 区心理学

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出版当年[2021]版：

Q3 OPHTHALMOLOGY Q4 NEUROSCIENCES Q4 PSYCHOLOGY

最新[2023]版：

Q3 PSYCHOLOGY Q3 OPHTHALMOLOGY Q4 NEUROSCIENCES

影响因子： 1.5 最新[2023版] 1.7 最新五年平均 1.984 出版当年[2021版] 2.766 出版当年五年平均 1.886 出版前一年[2020版] 1.8 出版后一年[2022版]

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第一作者机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730 China

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