机构：[1]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.[2]National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, PR China.[3]Xiangya School of Medicine, Central South University, Changsha, Hunan, PR China.[4]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Diabetic macular edema (DME) is a common complication of diabetic retinopathy and is the leading cause of vision loss in diabetic patients. Various factors, such as metabolic disorders and inflammation caused by hyperglycemia, are involved in the occurrence and development of DME, but the specific mechanism is still unclear. Müller cells are a type of macroglial cell unique to the fundus, distributed throughout the retina, and they play a unique role in retinal homeostasis. This article reviews the role of Müller cells in the pathological process of DME and the research progress in the treatment of DME by targeting Müller cells through gene therapy.
基金：
National Natural Science Foundation of China
(81970811) and the Domestic Science and Technology Cooperation Project of Shanghai Municipal Science and Technology Commission (21015800700).
第一作者机构：[1]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.[2]National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, PR China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.[2]National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, PR China.[4]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.[*1]Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, PR China
推荐引用方式(GB/T 7714)：
Lai Dongwei,Wu Yang,Shao Chuhan,et al.The Role of Müller Cells in Diabetic Macular Edema[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2023,64(10):doi:10.1167/iovs.64.10.8.
APA：
Lai Dongwei,Wu Yang,Shao Chuhan&Qiu Qinghua.(2023).The Role of Müller Cells in Diabetic Macular Edema.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,64,(10)
MLA：
Lai Dongwei,et al."The Role of Müller Cells in Diabetic Macular Edema".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 64..10(2023)
医学