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Role and mechanism of FLT4 in high-fat diet-induced obesity in mice

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收录情况： ◇ SCIE

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机构： [1]Department of Pediatrics, Beijing TongRen Hospital, Capital Medical University, Beijing, China [2]Department of Biochemistry and Immunology, Capital Institute of Pediatrics, Beijing, China [3]Beijing Municipal Key Laboratory of Child Development and Nutriomics, Beijing, China [4]Graduate School of Peking Union Medical College, Beijing, China [5]Department of Biochemistry and Immunology, Capital Institute of Pediatrics-Peking University Teaching Hospital, Beijing, China

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The FLT4 gene plays an important role in the onset and progression of obesity and is involved in the structure and function of lymphatic vessels. By inducing a mouse obesity model with a high-fat diet and knocking out the FLT4 gene, which is associated with lymphatic vessel growth in mice, FLT4+/- mice were found to be susceptible to high-fat diet-induced obesity, with significant accumulation of visceral fat. BODIPY™ FL C16 imaging revealed dilated and branched mesenteric lymphatic vessels in FLT4+/- mice. Immunofluorescence staining showed that FLT4+/- exacerbated the morphological abnormalities of lymphatic vessels and submucosal lymphatic vessels in visceral adipose tissue of obese mice, accompanied by macrophage infiltration around lymphatic vessels. In addition, FLT4 knock down increased the proportion of M1-type macrophages in the adipose tissue of the epididymis, indicating significant chronic inflammation in FLT4+/- obese mice. These findings provide new evidence for the involvement of lymphatic vessel morphological abnormalities in the onset and progression of obesity and highlight the importance of further investigation of FLT4 to better understand the mechanism of HFD-induced obesity and to develop related treatments.Copyright © 2023 Elsevier Inc. All rights reserved.

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出版当年[2022]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

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出版当年[2021]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 3.322 出版当年[2021版] 3.498 出版当年五年平均 3.575 出版前一年[2020版] 3.1 出版后一年[2022版]

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第一作者机构： [1]Department of Pediatrics, Beijing TongRen Hospital, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Department of Pediatrics, Beijing TongRen Hospital, Capital Medical University, Beijing, China [2]Department of Biochemistry and Immunology, Capital Institute of Pediatrics, Beijing, China [3]Beijing Municipal Key Laboratory of Child Development and Nutriomics, Beijing, China [4]Graduate School of Peking Union Medical College, Beijing, China [5]Department of Biochemistry and Immunology, Capital Institute of Pediatrics-Peking University Teaching Hospital, Beijing, China [*1]Beijing TongRen Hospital, Capital Medical University, Beijing, China.

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