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Personalized brain MRI revealed distinct functional and anatomical disruptions in Creutzfeldt-Jakob disease and Alzheimer's disease

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机构： [1]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Changping Laboratory, Beijing, China. [3]School of Engineering Medicine, Beihang University, Beijing, China. [4]Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. [5]Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. [6]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. [7]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. [8]Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. [9]Department of Neurology, Lishilu Outpatient, Jingzhong Medical District, Chinese PLA General Hospital, Beijing, China. [10]State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. [11]Biomedical Pioneering Innovation Center, Peking University, Beijing, China.

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Creutzfeldt-Jakob disease (CJD) is a lethal neurodegenerative disorder, which leads to a rapidly progressive dementia. This study aimed to examine the cortical alterations in CJD, changes in these brain characteristics over time, and the differences between CJD and Alzheimer's disease (AD) that show similar clinical manifestations.To obtain reliable, subject-specific functional measures, we acquired 24 min of resting-state fMRI data from each subject. We applied an individual-based approach to characterize the functional brain organization of 10 patients with CJD, 8 matched patients with AD, and 8 normal controls. We measured cortical atrophy as well as disruption in resting-state functional connectivity (rsFC) and then investigated longitudinal brain changes in a subset of CJD patients.CJD was associated with widespread cortical thinning and weakened rsFC. Compared with AD, CJD showed distinct atrophy patterns and greater disruptions in rsFC. Moreover, the longitudinal data demonstrated that the progressive cortical thinning and disruption in rsFC mainly affected the association rather than the primary cortex in CJD.CJD shows unique anatomical and functional disruptions in the cerebral cortex, distinct from AD. Rapid progression of CJD affects both the cortical thickness and rsFC in the association cortex.© 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

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出版当年[2022]版：

Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY Q1 NEUROSCIENCES

影响因子： 4.8 最新[2023版] 5.9 最新五年平均 5.5 出版当年[2022版] 6.2 出版当年五年平均 7.035 出版前一年[2021版] 4.8 出版后一年[2023版]

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第一作者机构： [1]Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

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通讯机构： [2]Changping Laboratory, Beijing, China. [11]Biomedical Pioneering Innovation Center, Peking University, Beijing, China. [*1]Changping Laboratory, No. 28 Zhongguancun Life Science Park, Beiqing Road, Beijing, China

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