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Structural and spontaneous functional brain changes in visual and oculomotor areas identified by functional localization task in intermittent exotropia children

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收录情况： ◇ SCIE

作者：
Fei Nanxi[1] * ; Wang Yachen[2,3] * ; Yang Bingbing[1] ; Zhang Chen[4] ; Chang Di[2,3] ; Liu Zhihan[2,3] ; Cheng Luyao[2,3] ; Fu Tao[2,3,*1] ; Xian Junfang[1,*2] ;
机构： [1]Department of Radiology,Beijing Tongren Hospital,Capital Medical University,100730 Beijing,China [2]Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,100730 Beijing,China [3]Beijing Ophthalmology & Visual Sciences Key Laboratory, 100730 Beijing, China [4]MR Scientific Marketing, Siemens Healthineers Ltd, 7, Wangjing Zhonghuan South Road, Chaoyang District, 100102 Beijing, China
出处：
DOI： 10.1016/j.brainres.2023.148543
ISSN：

关键词： Intermittent exotropia Gray matter density Cortical thickness Spontaneous functional activity Functional connectivity

摘要：
Intermittent exotropia (IXT) is characterizedby an intermittent outward deviation of the eyes. Yet, the neural substrates associated with IXT are not fully understood. This study investigated brain structure and spontaneous functional activity changes in children with IXT. All participants underwent detailed ophthalmological examinations and multimodal magnetic resonance imaging (MRI) scanning. During functional scanning, binocular visual stimuli were presented to subjects to determine brain areas involved in visual and oculomotor processing. Regions of interest(ROI) were subsequently selected based on functional activation to investigate brain structural and spontaneous functional differences between IXT children and healthy controls (HCs) using small volume correction (SVC). Reduced gray matter density (GMD) was found in the right frontal eye field (FEF) and bilateral inferior parietal lobe (IPL) in IXT children compared with HCs. Besides, reduced fractional amplitude of low-frequency fluctuations (fALFF) values were observed in the left lingual gyrus, right inferior occipital gyrus (IOG), bilateral IPL, and bilateral cerebellum in the IXT children compared to the HCs. IXT children with worse eye position control ability exhibited lower GMD and fALFF values in these areas. Finally, resting state functional connectivity (RSFC) was reduced in frontoparietal oculomotor processing areas in IXT children compared to HCs. In addition, increased cortical thickness was found in the right visual areas and bilateral IPL. These results showed that IXT-related structural and functional brain abnormalities occurred in childhood and may be related to underlying neuropathological mechanisms.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This work was supported by the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Supportsin China (grant number ZYLX201704), and Beijing Municipal Administration of Hospitals’ Ascent Plan (grant number DFL20190203), the National Natural Science Foundation of China (grant number 82071906, 81871340, 81571649, and 82071001), Natural Science Foundation of Beijing Municipality (grant number 7222030), National Key R&D Program of China (2022YFC2404005), and the priming scientific research foundation for the junior researcher in Beijing Tongren Hospital, Capital Medical University [2020-YJJ-ZZL-045].
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 4 区 神经科学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
JCR分区：
出版当年[2021]版：
Q3 NEUROSCIENCES
最新[2023]版：
Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Radiology,Beijing Tongren Hospital,Capital Medical University,100730 Beijing,China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Radiology,Beijing Tongren Hospital,Capital Medical University,100730 Beijing,China [2]Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,100730 Beijing,China [3]Beijing Ophthalmology & Visual Sciences Key Laboratory, 100730 Beijing, China [*1]Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing,No.1 of Dongjiaominxiang Street,China [*2]Department of Radiology,Beijing Tongren Hospital,Capital Medical University,Beijing,No.1 of Dongjiaominxiang Street,China
推荐引用方式(GB/T 7714)：
Fei Nanxi,Wang Yachen,Yang Bingbing,et al.Structural and spontaneous functional brain changes in visual and oculomotor areas identified by functional localization task in intermittent exotropia children[J].Brain research.2023,1819:148543.doi:10.1016/j.brainres.2023.148543.
APA：
Fei Nanxi,Wang Yachen,Yang Bingbing,Zhang Chen,Chang Di...&Xian Junfang.(2023).Structural and spontaneous functional brain changes in visual and oculomotor areas identified by functional localization task in intermittent exotropia children.Brain research,1819,
MLA：
Fei Nanxi,et al."Structural and spontaneous functional brain changes in visual and oculomotor areas identified by functional localization task in intermittent exotropia children".Brain research 1819.(2023):148543

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