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Extracellular vesicles from human umbilical cord mesenchymal stem cells prevent steroid-induced avascular necrosis of the femoral head via the PI3K/AKT pathway

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收录情况： ◇ SCIE

作者：
Peng Puji[1,2] * ; Wang XueZhong[3] * ; Qiu Chen[4] ; Zheng Wendi[1,2,*1] ; Zhang Hongjun[1,2,*1] ;
机构： [1]Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou, 450003, China [2]Department of Orthopedics, Zhengzhou University People’s Hospital, Zhengzhou, 450003, China [3]Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China [4]Department of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, 430000, China
出处：
DOI： 10.1016/j.fct.2023.114004
ISSN：

关键词： Human umbilical cord mesenchymal stem cells Extracellular vesicles Steroid-induced avascular necrosis of the femoral head PI3K/AKT pathway Apoptosis

摘要：
Extracellular vesicles (EVs) secreted by human umbilical cord mesenchymal stem cells (hucMSC) have excellent therapeutic potential for many diseases. The aim of this study was to define the role of hucMSC-EVs in the prevention and treatment of steroid-induced avascular necrosis of the femoral head (SANFH). After establishing the SANFH rat model, the effects of hucMSC-EVs were assessed by measuring the microstructure of the femoral head using HE staining, micro-computed tomography (micro-CT), and TUNEL staining. The administration of hucMSC-EVs caused a significant reduction to glucocorticoids (GCs)-induced osteoblast apoptosis and empty lacuna of the femoral head, while effectively improving the microstructure. HucMSC-EVs rescued the deactivation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway induced by GCs, and reversed the proliferation and migration of osteoblasts inhibited by GCs. In addition, hucMSC-EVs attenuated the inhibitory effects of GCs on rat osteoblast osteogenesis, angiogenesis of endothelial cells, and prevented osteoblast apoptosis. However, the promoting effects of hucMSC-EVs were abolished following the blockade of PI3K/AKT on osteoblasts. hucMSC-EVs were found to prevent glucocorticoid-induced femoral head necrosis in rats through the PI3K/AKT pathway.Copyright © 2023. Published by Elsevier Ltd.

基金：
This work was funded by grants from the Joint Construction Project of Henan Provincial Health Committee and Ministry of Health (SB201903016), National Natural Science Foundation of China (82002300), Key Research and Development and Promotion of Special Projects of Henan (Scientific and Technological Research, 232102310327) and Henan Province Young and Middle-aged Health Science and Technology Innovation Outstanding Young Talent Training Project (YXKC2021046).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 农林科学
小类 | 1 区 毒理学 2 区 食品科技
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 食品科技 3 区 毒理学
JCR分区：
出版当年[2021]版：
Q1 FOOD SCIENCE & TECHNOLOGY Q1 TOXICOLOGY
最新[2023]版：
Q1 TOXICOLOGY Q2 FOOD SCIENCE & TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou, 450003, China [2]Department of Orthopedics, Zhengzhou University People’s Hospital, Zhengzhou, 450003, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou, 450003, China [2]Department of Orthopedics, Zhengzhou University People’s Hospital, Zhengzhou, 450003, China [*1]Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou, 450003, China.
推荐引用方式(GB/T 7714)：
Peng Puji,Wang XueZhong,Qiu Chen,et al.Extracellular vesicles from human umbilical cord mesenchymal stem cells prevent steroid-induced avascular necrosis of the femoral head via the PI3K/AKT pathway[J].FOOD AND CHEMICAL TOXICOLOGY.2023,180:doi:10.1016/j.fct.2023.114004.
APA：
Peng Puji,Wang XueZhong,Qiu Chen,Zheng Wendi&Zhang Hongjun.(2023).Extracellular vesicles from human umbilical cord mesenchymal stem cells prevent steroid-induced avascular necrosis of the femoral head via the PI3K/AKT pathway.FOOD AND CHEMICAL TOXICOLOGY,180,
MLA：
Peng Puji,et al."Extracellular vesicles from human umbilical cord mesenchymal stem cells prevent steroid-induced avascular necrosis of the femoral head via the PI3K/AKT pathway".FOOD AND CHEMICAL TOXICOLOGY 180.(2023)

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