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Prevalence and Cause of Loss of Visual Acuity and Visual Field in Highly Myopic Eyes. The Beijing Eye Study

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资源类型：
Pubmed体系：
作者：
Jonas Jost B[1,2,3,4,5] * ; Jonas Rahul A[6] ; Xu Jie[1] ; Wang Ya Xing[1,*1] ;
机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beiing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China [2]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany [3]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany [4]Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland [5]Singapore Eye Research Institute, Singapore [6]Department of Ophthalmology, University of Cologne, Cologne, Germany
出处：
DOI： 10.1016/j.ophtha.2023.08.026
ISSN：

摘要：
To explore prevalence and causes of loss of visual acuity and visual field in highly myopic eyes.Population-based study.The participants (n=4439) of the Beijing Eye Study underwent an ophthalmological and systemic examination including frequency doubling technology perimetry (FDT).High myopia was defined by a refractive error of ≤-6Dpt or axial length >26.0 mm.Prevalence of vision impairment causes.The study included 212 highly myopic eyes (154 participants;mean age:56.2±9.6 years;refractive error:-9.87±3.70 Dpt;range:-20.87 to -6.00Dpt; axial length:27.2±1.3mm;range:26.01-30.88mm). Moderate/severe vision impairment (MSVI) (best corrected visual acuity (BCVA) from <6/18 to 3/60) and blindness (BCVA <3/60 or <10° visual field around central fixation) was present in 40/212 (18.9%;95%CI:13.6,24.2) eyes, and in 10/212 (4.7%;95%CI:1.8, 7.6) eyes, respectively. BCVA decreased with more myopic refractive error (beta:-0.55;B:-0.08;95%CI:-0.09,-0.06;P<0.001). Primary (i.e., most influential) causes for MSVI and blindness were myopic macular degeneration (MMD) (29/50;58%), age-related macular degeneration (1/50;2%), and branch macular retinal vein occlusion (1/50;2%). Secondary causes were MMD (4/50;8%) and optic nerve atrophy (14/50 (28%), differentiated into a non-glaucomatous type (NGOA) (9/50;18%) and glaucomatous type (GOA) (5/50;10%). Prevalence of MMD as vision impairment cause (mean:40/212 (18.9%;95%CI:13.6,24.2) increased from 1/61 (1.6%;95%CI:0.00,4.9) in the group of -6.00 to ≥-7.00Dpt, to 16/25 (64.0%;95%CI:43.8,84.2) in the group of <-15.0Dpt. Higher MMD prevalence correlated with higher myopic refractive error (OR:0.70;95%CI:0.61;0.81;P<0.001) and higher prevalence of concomitant optic neuropathy (OR:86.2;95%CI:16.1,463;P<0.001). Optic neuropathy prevalence as cause of vision impairment (mean:19/212;9.0%;95%CI:5.0,13.0) increased from 0/61 (0%) in the refractive error group of -6.00Dpt to ≥-7.00Dpt, to 9/25 (36.0%;95%CI:16.0,56.0) in the group of <-15.0Dpt. Higher optic neuropathy prevalence correlated with more myopic refractive error (P<0.001) and older age (P=0.02). GOA prevalence (mean:6/212;2.8%;95%CI:1.0,5.0) and NGOA prevalence (mean:13/212 (6.1%;95%CI:3.0,9.0) increased from 0/61 (0%) in the group of -6.00 to ≥-7.00Dpt, to 4/25 (16.0%;95%CI:1.0,31.0) and 5/25 (20%;95%CI:3.0,37.0), respectively, in the group of <-15.0Dpt.In this population-based recruited, highly myopic cohort, prevalence of optic neuropathy (9.0%) as vision impairment cause was lower than MMD prevalence (18.9%), and it was an important reason for vision impairment in the group of <-15Dpt. MMD was vision impairment cause in 16/25 (64.0%) eyes with <-15.0Dpt refractive error.Copyright © 2023. Published by Elsevier Inc.

基金：
Research Development Fund of Beijing Municipal Health Commission (2019-4); National Natural Science Foundation of China (82271086
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
第一作者：
第一作者机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beiing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China [2]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany [3]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany [4]Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland [5]Singapore Eye Research Institute, Singapore
通讯作者：
通讯机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beiing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China [*1]Beijing Tongren Hospital, 1 Dongjiaomin Lane, Dongcheng, 100730, Beijing, China
推荐引用方式(GB/T 7714)：
Jonas Jost B,Jonas Rahul A,Xu Jie,et al.Prevalence and Cause of Loss of Visual Acuity and Visual Field in Highly Myopic Eyes. The Beijing Eye Study[J].Ophthalmology.2023,doi:10.1016/j.ophtha.2023.08.026.
APA：
Jonas Jost B,Jonas Rahul A,Xu Jie&Wang Ya Xing.(2023).Prevalence and Cause of Loss of Visual Acuity and Visual Field in Highly Myopic Eyes. The Beijing Eye Study.Ophthalmology,,
MLA：
Jonas Jost B,et al."Prevalence and Cause of Loss of Visual Acuity and Visual Field in Highly Myopic Eyes. The Beijing Eye Study".Ophthalmology .(2023)

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