To assess the prevalence of and risk factors for fundus pathology in patients with type 2 diabetes mellitus (T2DM) in a cohort from northeastern China.Patients were included from the Fushun Diabetic Retinopathy Cohort Study. Patients aged ≥ 30 years with T2DM were recruited between July 2012 and May 2013. Fundus pathology included retinal vascular occlusion (RVO), age-related macular degeneration (AMD), macular pathology, pathologic myopia (PM) and glaucomatous optic atrophy (GOA).A Total of 1998 patients with gradable fundus photographs were included in this study, of whom 388 (19.42%) had fundus pathology regardless of whether they had diabetic retinopathy (DR). There were 187 (9.36%) patients with AMD, 97 (4.85%) with GOA, 67 (3.35%) with macular pathology, 35 (1.75%) with PM and 23 (1.15%) with RVO. Advanced age was significantly associated with AMD (odds ratio (OR), 95% confidence interval (CI): 1.03, 1.01-1.05), macular pathology (OR, 95% CI: 1.06, 1.03-1.09) and GOA (OR, 95% CI: 1.06, 1.04-1.09). A wider central retinal arteriolar equivalent was protective against PM (OR, 95% CI: 0.78, 0.66-0.92). Wider central retinal venular equivalent was a protective factor for PM (OR, 95% CI: 0.75, 0.68-0.82) and GOA (OR, 95% CI: 0.93, 0.87-0.99).One-fifth of these patients in northeast China with T2DM had fundus pathology regardless of whether they had DR, indicating the importance of early screening and long-term follow-up.
基金：
Wenzhou Basic Medical and
Health Technology Project (Y20210995), Innovation Project
of School of Ophthalmology and Optometry, Eye Hospital of
Wenzhou Medical University (YNCX3201905), and Liaoning
Provincial Natural Science Foundation of China
(20170540328).
第一作者机构：[1]National Clinical Research Center for Ocular Diseases, Wenzhou, China.[2]Eye Hospital, Wenzhou Medical University, Wenzhou, China.
通讯作者：
通讯机构：[1]National Clinical Research Center for Ocular Diseases, Wenzhou, China.[2]Eye Hospital, Wenzhou Medical University, Wenzhou, China.[3]Fushun Eye Hospital, Fushun, Liaoning, China.[*1]Fushun Eye Hospital, No.1 Hu Po Quan Street, Xin Fu District, Fushun, Liaoning 113006, China[*2]National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
推荐引用方式(GB/T 7714)：
Lin Wei,Li Dong,Wen Liang,et al.Prevalence and Risk Factors of Fundus Pathology in Patients with Type 2 Diabetes in a Northeastern Chinese Cohort[J].OPHTHALMIC EPIDEMIOLOGY.2024,31(4):356-363.doi:10.1080/09286586.2023.2260855.
APA：
Lin Wei,Li Dong,Wen Liang,Wang Yu,Lin Zhong...&Liang Yuanbo.(2024).Prevalence and Risk Factors of Fundus Pathology in Patients with Type 2 Diabetes in a Northeastern Chinese Cohort.OPHTHALMIC EPIDEMIOLOGY,31,(4)
MLA：
Lin Wei,et al."Prevalence and Risk Factors of Fundus Pathology in Patients with Type 2 Diabetes in a Northeastern Chinese Cohort".OPHTHALMIC EPIDEMIOLOGY 31..4(2024):356-363
