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Effect of 3% Diquafosol Sodium on Dry Eye After Femtosecond Laser-Assisted In Situ Keratomileusis and Small Incision Lenticule Extraction Surgery in High-Myopic Eyes

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收录情况： ◇ SCIE

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机构： [1]Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

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To evaluate the effect of 3% diquafosol sodium eye drop on dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and small incision lenticule extraction (SMILE) in high-myopic eyes.Eighty-one cases with high myopia (162 eyes) who received FS-LASIK or SMILE were divided into four groups by surgical design and tear film stability: D-FS-LASIK (5s <breakup time [BUT] <10s) and D-SMILE (5s <BUT <10s) were treated with 3% diquafosol sodium and 0.3% sodium hyaluronate eye drops, C-FS-LASIK and C-SMILE (BUT ≥10s) treated with 0.3% sodium hyaluronate. Follow-up points were performed preoperatively and at 1 week, 1 month, and 3 months postoperatively. Schirmer I test, BUT, fluorescein staining, and objective optical quality were measured, and questionnaires were acquired.The D-SMILE group showed increase in BUT postoperatively (1m: P=0.006, 3m: P=0.004), whereas C-FS-LASIK (1m: P=0.012) and C-SMILE (1m: P=0.036) groups showed decrease in BUT. Higher ΔBUT were observed in D-FS-LASIK (1m: P=0.027) and D-SMILE (1m: P=0.001, 3m: P=0.012) postoperatively. The D-FS-LASIK group showed less decrease than C-FS-LASIK group in Schirmer I. The D-SMILE group showed increase in Schirmer I, whereas C-SMILE showed decrease in 3 months. ΔOSDI was lower in D-SMILE group than in C-SMILE group (1m: P=0.026, 3m: P=0.035). Fatigue was severer in D-SMILE group than in C-SMILE group preoperatively (P=0.019), although there was no significant difference postoperatively. Objective scattering index (1m: P=0.002, 3m: P=0.021) and tear film objective scattering index (1m: P=0.005, 3m: P=0.010) were lower in D-FS-LASIK group than in C-FS-LASIK group postoperatively. The D-FS-LASIK group showed better VA20% (P=0.036) and VA9% (P=0.027) than the C-FS-LASIK group 1 month postoperatively.3% Diquafosol sodium eye drop was effective for SMILE and FS-LASIK-related dry eye in high-myopic eyes. It is necessary to focus on perioperative anti-dry eye management and especially pay attention to the eyes with risk factors, including unstable tear film, high myopia, and FS-LASIK surgery.Copyright © 2023 Contact Lens Association of Ophthalmologists.

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区眼科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区眼科学

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出版当年[2021]版：

Q2 OPHTHALMOLOGY

最新[2023]版：

Q2 OPHTHALMOLOGY

影响因子： 2 最新[2023版] 2.3 最新五年平均 3.152 出版当年[2021版] 2.89 出版当年五年平均 2.018 出版前一年[2020版] 2.3 出版后一年[2022版]

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第一作者机构： [1]Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

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通讯机构： [1]Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [*1]Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No 1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China

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