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Deep neuromuscular block attenuates intra-abdominal pressure and inflammation and improves post-operative cognition in prostate cancer patients following robotic-assisted radical prostatectomy

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收录情况： ◇ SCIE

作者：
Hu Guangjun[1,*1] * ; Shao Weidong[2] ; Chen Zhuo[1] ; Li Bixi[3] ; Xu Bo[2] ;
机构： [1]Department of Anesthesiology, Wuhan Third Hospital/Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. [2]Department of Anesthesiology, General Hospital of the Southern Theater Command of the Chinese PLA, Guangzhou, Guangdong Province, China. [3]Department of Anesthesiology, General Hospital of the Central Theater Command of the Chinese PLA, Wuhan, Hubei Province, China.
出处：
DOI： 10.1002/rcs.2565
ISSN：

关键词： Deep neuromuscular block (DNMB) Intra‐abdominal pressure (IAP) Moderate neuromuscular block (MNMB) Mini‐mental State Examination (MMSE) Post‐tetanic counts Prostate cancer Prostate cancer (PC) Robotic‐assisted laparoscopic radical prostatectomy (RALRP)

摘要：
Whether neuromuscular block (NMB) affects Intra-abdominal pressure (IAP) and cognition in Prostate cancer (PC) patients with Robotic-assisted laparoscopic radical prostatectomy (RALRP) remains unclear. Here we aimed to compare the effects of deep and moderate NMB on the IAP, inflammation, and cognition.The Moderate neuromuscular block (MNMB) group (N = 44) and Deep neuromuscular block (DNMB) group (N = 47) were recruited. Intra-abdominal pressure was adjusted to meet RALRP requirements. The expression of pro-inflammatory factors was measured by ELISA. MMSE scores were recorded before the operation, 1 day and 1 week after the operation.Significant decreases in IAP (p < 0.001) and IL-1β, IL-6, TNF-a, and S-100β (p ≤ 0.01) expressions were found in the DNMB group. The MMSE score in the DNMB group was higher than that in the MNMB group on day one (p = 0.046). The incidence of nausea and vomiting was lower in the DNMB group than that in the MNMB group (p = 0.013).DNMB reduces IAP and inflammation and improves post-operative cognitive functions in PC patients with RALRP.© 2023 John Wiley & Sons Ltd.

基金：
This work was supported by the Guangzhou Science and Technology Project [grant number 201904010389], the National Natural Science Foundation of China [grant number 62076253], the Wuhan Medical Research Project [grant number WX21D09], and the Hubei Provincial Natural Science Foundation [grant number 2023AFB864].
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 外科
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 外科
JCR分区：
出版当年[2022]版：
Q2 SURGERY
最新[2023]版：
Q2 SURGERY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Anesthesiology, Wuhan Third Hospital/Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. [*1]Department of Anesthesiology, Wuhan Third Hospital/Tongren Hospital of Wuhan University, 241 Pengliuyang Road, Wuhan, Hubei Province, China.
通讯作者：
通讯机构： [1]Department of Anesthesiology, Wuhan Third Hospital/Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. [*1]Department of Anesthesiology, Wuhan Third Hospital/Tongren Hospital of Wuhan University, 241 Pengliuyang Road, Wuhan, Hubei Province, China.
推荐引用方式(GB/T 7714)：
Hu Guangjun,Shao Weidong,Chen Zhuo,et al.Deep neuromuscular block attenuates intra-abdominal pressure and inflammation and improves post-operative cognition in prostate cancer patients following robotic-assisted radical prostatectomy[J].INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY.2024,20(1):doi:10.1002/rcs.2565.
APA：
Hu Guangjun,Shao Weidong,Chen Zhuo,Li Bixi&Xu Bo.(2024).Deep neuromuscular block attenuates intra-abdominal pressure and inflammation and improves post-operative cognition in prostate cancer patients following robotic-assisted radical prostatectomy.INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY,20,(1)
MLA：
Hu Guangjun,et al."Deep neuromuscular block attenuates intra-abdominal pressure and inflammation and improves post-operative cognition in prostate cancer patients following robotic-assisted radical prostatectomy".INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY 20..1(2024)

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