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Finite element analysis of repairing tympanic membrane perforation using autologous graft material and biodegradable bionic cobweb scaffold

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收录情况： ◇ SCIE

作者：
Wang Liang[1] * ; Han Hongge[1] ; Wang Jie[2,3] ; Zhu Yueting[4] ; Liu Zhanli[5] ; Sun Yongtao[1,6,*1,*2] ; Wang Lele[1] ; Xiang Shuyi[5] ; Shi Huibin[5] ; Ding Qian[1] ;
机构： [1]Department of Mechanics and Tianjin Key Laboratory of Nonlinear Dynamics and Control, Tianjin University, Tianjin 300350, China [2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing 100730, China [3]Beijing Engineering Research Center of Audiological Technology, Beijing 100730, China [4]Department of Otolaryngology, Head and Neck Surgery, Tianjin Children’s Hospital, Tianjin University, Tianjin 300400, China [5]School of Aerospace Engineering, Tsinghua University, Beijing 100084, China [6]National Key Laboratory of Strength and Structural Integrity, Xian, Shaanxi 710065, China
出处：
DOI： 10.1016/j.cmpb.2023.107868
ISSN：

摘要：
As for repairing the perforated tympanic membranes (TM), temporalis fascia and tragal cartilage are popular in clinics as autologous graft materials. However, there is a significant hearing loss after repairing the TM with autologous graft materials, which needs to be addressed in biomechanical engineering.The finite element model of normal middle ear is improved from two aspects: the repair method of tympanic fibrous layer and the bionic spider web tympanic scaffold. By creating the solid-shell coupling condition and strong coupling boundary condition to simulate the repair, TM umbo and stapes footplate displacement-frequency response are explored in 200-8000 Hz.The tympanic membrane perforation (TMP) causes a significant conductive hearing loss in high frequency region, which is positively correlated with perforation area. Both temporalis fascia and tragal cartilage still perform a certain degree of high-frequency hearing loss after repairing TMP. The TM attachment the magnesium alloy scaffold (MAS) prevents appropriately the high frequency hearing loss after autologous graft repair and makes the sound transmission closer to the normal condition. Significantly, the density of graft material has a negative effect on high-frequency sound transmission without the MAS. The modal-motion of TM repaired with temporalis fascia and tragal cartilage is improved significantly after attaching the MAS. In addition, the MAS restores effectively the configuration and vibration frequency of the repaired TM, which is similar to that of the native TM.The area size of TMP is studied through the finite element method, which includes autologous graft materials, the MAS, parameter sensitivity analysis, modal analysis of graft material and the MAS in biological form on the effect of middle ear sound transmission. Relevant conclusions provide some references for clinical trial protocol and the follow-up repair ideas of TM of tympanoplasty.Copyright © 2023. Published by Elsevier B.V.

基金：
The project was supported by the National Natural Science Foundation of China (Grant No. 12372019, 12072222, 12132010, 12021002, 11991032), the Open Projects of State Key Laboratory for Strength and Structural Integrity (Grant No. ASSIKFJJ202303002), the State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures (Grant No. SKLTESKF1901), and the Aeronautical Science Foundation of China (Grant No. ASFC-201915048001).
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出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 计算机：跨学科应用 2 区 计算机：理论方法 2 区 工程：生物医学 2 区 医学：信息
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 计算机：跨学科应用 2 区 计算机：理论方法 2 区 工程：生物医学 2 区 医学：信息
JCR分区：
出版当年[2022]版：
Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Q1 COMPUTER SCIENCE, THEORY & METHODS Q1 ENGINEERING, BIOMEDICAL Q1 MEDICAL INFORMATICS
最新[2023]版：
Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Q1 COMPUTER SCIENCE, THEORY & METHODS Q1 ENGINEERING, BIOMEDICAL Q1 MEDICAL INFORMATICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Mechanics and Tianjin Key Laboratory of Nonlinear Dynamics and Control, Tianjin University, Tianjin 300350, China
通讯作者：
通讯机构： [1]Department of Mechanics and Tianjin Key Laboratory of Nonlinear Dynamics and Control, Tianjin University, Tianjin 300350, China [6]National Key Laboratory of Strength and Structural Integrity, Xian, Shaanxi 710065, China [*1]Department of Mechanics and Tianjin Key Laboratory of Nonlinear Dynamics and Control, Tianjin University, Tianjin 300350, China [*2]National Key Laboratory of Strength and Structural Integrity, Xian, Shaanxi 710065, China.
推荐引用方式(GB/T 7714)：
Wang Liang,Han Hongge,Wang Jie,et al.Finite element analysis of repairing tympanic membrane perforation using autologous graft material and biodegradable bionic cobweb scaffold[J].COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE.2024,243:107868.doi:10.1016/j.cmpb.2023.107868.
APA：
Wang Liang,Han Hongge,Wang Jie,Zhu Yueting,Liu Zhanli...&Ding Qian.(2024).Finite element analysis of repairing tympanic membrane perforation using autologous graft material and biodegradable bionic cobweb scaffold.COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE,243,
MLA：
Wang Liang,et al."Finite element analysis of repairing tympanic membrane perforation using autologous graft material and biodegradable bionic cobweb scaffold".COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 243.(2024):107868

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