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Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the SHINY study

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收录情况： ◇ SCIE

作者：
Gao Liqin[1] * ; Song Yanping[2] ; Sun Xiaodong[3] ; Zhang Junjun[4] ; Liu Yuling[5] ; Chen Youxin[6] ; Wu Zhifeng[7] ; Jian Ye[8] ; Liu Xiaoling[9] ; Lv Lin[10] ; Chen Shaojun[11] ; Wang Yu-Sheng[12] ; Chen Nan[13] ; Ke Xiao[14] ; Zhang Feng[1] ;
机构： [1]Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China. [2]Department of Ophthalmology, Chinese PLA General Hospital of Central Theater Command, Wuhan, China. [3]Department of Ophthalmology, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai, China. [4]Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, China. [5]Department of Ophthalmology, Peking University Third Hospital, Beijing, China. [6]Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China. [7]Department of Ophthalmology, Wuxi No.2 People's Hospital, Nanjing Medical University, Wuxi, China. [8]Department of Ophthalmology, Daping Hospital and Institute of Surgery Research, Army Medical University, Chongqing, China. [9]National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. [10]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. [11]Department of Ophthalmology, He Eye Specialist Hospital, Chongqing, China. [12]Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an, China. [13]Department of Ophthalmology, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China. [14]Medical Research Center, Chengdu Kanghong Biotechnology Inc, Chengdu, China.
出处：
DOI： 10.1111/aos.15810
ISSN：

关键词： best-corrected visual acuity central retinal thickness choroidal neovascularization

摘要：
To evaluate the safety and efficacy of intravitreal injections of 0.5 mg conbercept in patients with choroidal neovascularization secondary to pathological myopia (pmCNV).The 177 pmCNV patients were randomly assigned in a 3:1 ratio to receive conbercept or sham injection, respectively. The conbercept group receive conbercept intravitreal injections administered on a pro re nata (PRN) basis after 3 monthly loading doses. The sham group received three consecutive monthly sham injections and then one conbercept injection followed by PRN conbercept intravitreal injections.At month 3, the mean BCVA for the two groups were improved by 12.0 letters (conbercept group, from 54.05 letters to 66.05 letters) and 0.6 letters (sham group, from 49.77 letters to 50.33 letters), respectively (p < 0.001). The mean central retinal thickness (CRT) at month 3 in the two groups decreased 62.0 μm (conbercept group, from 348.90 μm to 286.18 μm) and 4.4 μm (sham group, from 347.86 μm to 343.47 μm) (p < 0.001). At month 9, the mean BCVA improved by 13.3 letters in the conbercept group and 11.3 letters in the sham group. The mean CRT decreased 73.6 μm in the conbercept group and 55.9 μm in the sham group (p < 0.001). The most common ocular adverse events were associated with intravitreal injections, such as conjunctival haemorrhage and increased intraocular pressure.Intravitreal injections of 0.5 mg conbercept provided improvement in visual and anatomical outcomes in pmCNV patients with low rates of ocular and nonocular safety events.© 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.

基金：
The study was supported by Chengdu Kanghong Biotechnology Inc. (number 36 ShuxiRoad, JinniuDistrict, Chengdu, China).
语种：
外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 2 区 眼科学
最新[2023]版：
大类 | 3 区 医学
小类 | 2 区 眼科学
JCR分区：
出版当年[2022]版：
Q2 OPHTHALMOLOGY
最新[2023]版：
Q1 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Gao Liqin,Song Yanping,Sun Xiaodong,et al.Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the SHINY study[J].ACTA OPHTHALMOLOGICA.2024,102(4):e577-e586.doi:10.1111/aos.15810.
APA：
Gao Liqin,Song Yanping,Sun Xiaodong,Zhang Junjun,Liu Yuling...&Zhang Feng.(2024).Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the SHINY study.ACTA OPHTHALMOLOGICA,102,(4)
MLA：
Gao Liqin,et al."Safety and efficacy of intravitreal injection of conbercept for the treatment of patients with choroidal neovascularization secondary to pathological myopia: Results from the SHINY study".ACTA OPHTHALMOLOGICA 102..4(2024):e577-e586

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