个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Abnormal white and gray matter functional connectivity is associated with cognitive dysfunction in presbycusis

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Yao[1,2] * ; Gao Yuting[1] ; Zhao Min[3] ; Hu Xin[3] ; Wang Jing[3] ; Han Yu[1] ; Wang Qinghui[4] ; Fu Xinxing[5] ; Dai Zongrui[6] ; Ren Funxin[3] ; Li Muwei[7,*1] ; Gao Fei[3,*2] ;
机构： [1]School of Life Sciences, Tiangong University, Tianjin 300387, China. [2]Tianjin Key Laboratory of Optoelectronic Detection Technology and System, Tiangong University, Tianjin 300387, China. [3]Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China. [4]Department of Radiology, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong, China. [5]Beijing Institute of Otolaryngology, Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100069, China. [6]Department of Biostatistics, University of Michigan Ann Arbor, Ann Arbor, MI 48109, United States. [7]Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
出处：
DOI： 10.1093/cercor/bhad495
ISSN：

关键词： cognitive impairment functional connectivity presbycusis white matter

摘要：
Presbycusis is characterized by high-frequency hearing loss and is closely associated with cognitive decline. Previous studies have observed functional reorganization of gray matter in presbycusis, but the information transmission between gray matter and white matter remains ill-defined. Using resting-state functional magnetic resonance imaging, we investigated differences in functional connectivity (GM-GM, WM-WM, and GM-WM) between 60 patients with presbycusis and 57 healthy controls. Subsequently, we examined the correlation between these connectivity differences with high-frequency hearing loss as well as cognitive impairment. Our results revealed significant alterations in functional connectivity involving the body of the corpus callosum, posterior limbs of the internal capsule, retrolenticular region of the internal capsule, and the gray matter regions in presbycusis. Notably, disrupted functional connectivity was observed between the body of the corpus callosum and ventral anterior cingulate cortex in presbycusis, which was associated with impaired attention. Additionally, enhanced functional connectivity was found in presbycusis between the internal capsule and the ventral auditory processing stream, which was related to impaired cognition in multiple domains. These two patterns of altered functional connectivity between gray matter and white matter may involve both bottom-up and top-down regulation of cognitive function. These findings provide novel insights into understanding cognitive compensation and resource redistribution mechanisms in presbycusis.© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

基金：
National Natural Science Foundation of China (Nos. 61701342, 81601479); Taishan Scholars Project of Shandong Province (No. tsqn201812147); Tianjin Natural Science Foundation (No. 19JCQNJC13100); Shandong Provincial Natural Science Foundation of China (grant nos. ZR2021MH030, ZR2021MH355); Jinan Science and Technology Development Program of China (No. 202019098); and the Academic Promotion Programme of Shandong First Medical University (grant no. 2019QL023).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 3 区 神经科学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
JCR分区：
出版当年[2022]版：
Q2 NEUROSCIENCES
最新[2023]版：
Q2 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]School of Life Sciences, Tiangong University, Tianjin 300387, China. [2]Tianjin Key Laboratory of Optoelectronic Detection Technology and System, Tiangong University, Tianjin 300387, China.
通讯作者：
通讯机构： [3]Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China. [7]Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, United States. [*1]Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S, Medical Center North, AA-1105, Nashville, TN 37232-2310, United States [*2]Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jingwu Road No. 324, Jinan 250021, China
推荐引用方式(GB/T 7714)：
Wang Yao,Gao Yuting,Zhao Min,et al.Abnormal white and gray matter functional connectivity is associated with cognitive dysfunction in presbycusis[J].CEREBRAL CORTEX.2024,34(1):doi:10.1093/cercor/bhad495.
APA：
Wang Yao,Gao Yuting,Zhao Min,Hu Xin,Wang Jing...&Gao Fei.(2024).Abnormal white and gray matter functional connectivity is associated with cognitive dysfunction in presbycusis.CEREBRAL CORTEX,34,(1)
MLA：
Wang Yao,et al."Abnormal white and gray matter functional connectivity is associated with cognitive dysfunction in presbycusis".CEREBRAL CORTEX 34..1(2024)

相关文献

[1]White Matter Changes in Patients with Amnestic Mild Cognitive Impairment Detected by Diffusion Tensor Imaging [2]Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study [3]rTMS regulates homotopic functional connectivity in the SCD and MCI patients [4]Impaired functional network properties contribute to white matter hyperintensity related cognitive decline in patients with cerebral small vessel disease [5]轻型缺血性卒中后认知障碍与脑动态功能连接状态改变的功能磁共振成像研究 [6]Free Water MRI of White Matter in Wilson's Disease [7]Abnormal postcentral gyrus voxel-mirrored homotopic connectivity as a biomarker of mild cognitive impairment: A resting-state fMRI and support vector machine analysis [8]早期认知功能损害患者脑组织谷氨酸代谢浓度变化的氢质子磁共振波谱相关研究 [9]Abnormal resting-state functional connectivity study in unilateral pulsatile tinnitus patients with single etiology: A seed-based functional connectivity study [10]Cochlear implantation in children with white matter lesions Prediction of hearing outcomes by multiple regression analysis

资源点击量：25471 今日访问量：0 总访问量：1498 更新日期：2025-06-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持：重庆聚合科技有限公司 地址：北京市东城区东交民巷1号(100730)