It has been demonstrated that interfering with the expression of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) results in impaired programmed death 1 ligand 1 (PD-L1) protein expression in human tumor cells. PD-L1 relies on CMTM6 to inhibit T cell responses and promote tumor cell proliferation. The aim of the present study was to investigate the expression of CMTM6 and PD-L1 in cervical cancer and their clinical significance. Immunohistochemistry was used to detect the expression of CMTM6 and PD-L1 in 50 normal cervical tissues and 102 cervical cancer tissue samples. The results showed that CMTM6 and PD-L1 expression was associated with clinical staging, lymph node metastasis, distant metastasis, and tumor differentiation. In addition, there was a positive association between the expression of CMTM6 and that of PD-L1 in cervical cancer tissue. Survival analysis results showed that high expression of CMTM6 and PD-L1 was positively correlated with poor prognosis in patients. Univariate analysis showed that lymph node metastasis was associated with the prognosis of cervical cancer patients. Cox analysis indicated that PD-L1 is a risk factor affecting the survival time of cervical cancer patients. In conclusion, the expression of CMTM6 and PD-L1 is elevated in cervical cancer tissue and closely related to poor prognosis. Therefore, CMTM6 and PD-L1 may be new molecular targets for the treatment of cervical cancer.
基金：
Medical Science Research Project in Hebei Province [20211171]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Pathol, Key Lab Head & Neck Mol Diag Pathol, Beijing 100730, Peoples R China[2]Cangzhou Peoples Hosp, Dept Pathol, Cangzhou 061000, Hebei, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Pathol, Key Lab Head & Neck Mol Diag Pathol, Beijing 100730, Peoples R China[2]Cangzhou Peoples Hosp, Dept Pathol, Cangzhou 061000, Hebei, Peoples R China[*1]De-partment of Pathology, Cangzhou People’s Hos-pital, Cangzhou 061000, Hebei, P. R. China[*2]Department of Pathology, Key Laboratory of Head and Neck Molecular Diagnosis Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P. R. China.
推荐引用方式(GB/T 7714)：
Ma Hongyan,Shi Shuai,Ma Zhihong,et al.Clinicopathologic and prognostic significance of CMTM6 and PD-L1 expression in cervical squamous cell carcinoma[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2023,16(12):368-377.
APA：
Ma, Hongyan,Shi, Shuai,Ma, Zhihong,Sun, Jie,Liu, Xiaoyun...&Zhang, Zhigang.(2023).Clinicopathologic and prognostic significance of CMTM6 and PD-L1 expression in cervical squamous cell carcinoma.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,16,(12)
MLA：
Ma, Hongyan,et al."Clinicopathologic and prognostic significance of CMTM6 and PD-L1 expression in cervical squamous cell carcinoma".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 16..12(2023):368-377
