机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]BeijingInstitute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]China Astronaut Research and Training Center, State Key Lab of SpaceMedicine Fundamentals and Application, No.26 Beiqing Road, Haidian District, Beijing 100094, China航天员中心[4]Xi’an No.1 Hospital ,Shanxi Institute of Ophthalmology ,Shanxi KeyLaboratory of Ophthalmology,Clinical Research Center for Ophthalmology Diseases of Shanxi Province ,the First Affiliated Hospital of Northwestern University, Xi’an 710002Shanxi Province, China
The elevation in the optic nerve sheath (ONS) pressure (ONSP) due to microgravity-induced headward fluid shift is the primary hypothesized contributor to SANS. This longitudinal study aims to quantify the axial plane of the optic nerve subarachnoid space area (ONSSA), which is filled with cerebrospinal fluid (CSF) and expands with elevated ONSP during and after head-down tilt (HDT) bed rest (BR). 36 healthy male volunteers (72 eyes) underwent a 90-day strict 6(degrees) HDT BR. Without obtaining the pre-HDT data, measurements were performed on days 30, 60, and 90 during HDT and at 6 recovery time points extended to 180-days (R + 180) in a supine position. Portable B-scan ultrasound was performed using the 12 MHz linear array probe binocularly. The measurements of the ONS and the calculation of the ONSSA were performed with ImageJ 1.51 analysis software by two experienced observers in a masked manner. Compared to R + 180, the ONSSA on HDT30, HDT60, and HDT90 exhibited a consistently significant distention of 0.44 mm(2) (95% CI: 0.13 to 0.76 mm(2), P = 0.001), 0.45 mm(2) (95% CI: 0.15 to 0.75 mm(2), P = 0.001), and 0.46 mm(2 )(95% CI: 0.15 to 0.76 mm(2), P < 0.001), respectively, and recovered immediately after HDT on R + 2. Such small changes in the ONSSA were below the lateral resolution limit of ultrasound (0.4 mm) and may not be clinically relevant, possibly due to ONS hysteresis causing persistent ONS distension. Future research can explore advanced quantitative portable ultrasound-based techniques and establish comparisons containing the pre-HDT measurements to deepen our understanding of SANS.
基金：
China Manned Space Advanced Research Project(ES-2-NO.0037);Space Medical Experiment Project of China Manned Space Program(HYZHXM01014) [ES-2-NO.0037]; China Manned Space Advanced Research Project [HYZHXM01014]; Space Medical Experiment Project of China Manned Space Program
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China[2]BeijingInstitute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Yuan Xie,Yingdi Fu,Yaqi Shao,et al.Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest[J].NPJ MICROGRAVITY.2024,10(1):doi:10.1038/s41526-024-00347-x.
APA：
Yuan Xie,Yingdi Fu,Yaqi Shao,Lina Qu,Jiangang Yang...&Yinghui Li.(2024).Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest.NPJ MICROGRAVITY,10,(1)
MLA：
Yuan Xie,et al."Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest".NPJ MICROGRAVITY 10..1(2024)
