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X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Markus Scholz [1,2] * ; Katrin Horn [1,2] * ; Janne Pott [1,2] ; Matthias Wuttke [3,4] ; Andreas Kühnapfel [1,2] ; M. Kamal Nasr [5,6,7] ; Holger Kirsten[1,2] ; Yong Li [3] ; Anselm Hoppmann[3] ; Mathias Gorski [8,9] ; Sahar Ghasemi[5,6] ; Man Li[10] ; Adrienne Tin [11,12] ; Jin-Fang Chai[13] ; Massimiliano Cocca [14] ; Judy Wang[15] ; Teresa Nutile [16] ; Masato Akiyama [17,18] ; Bjørn Olav Åsvold [19,20] ; Nisha Bansal[21,22] ; Mary L. Biggs[23,24] ; Thibaud Boutin[25] ; Hermann Brenner [26,27] ; Ben Brumpton [19,28,29] ; Ralph Burkhardt [2,30] ; Jianwen Cai [31] ; Archie Campbell [32] ; Harry Campbell[33] ; John Chalmers[34] ; Daniel I. Chasman [35,36] ; Miao Ling Chee[37] ; Miao Li Chee[37] ; Xu Chen[38] ; Ching-Yu Cheng [37,39,40] ; Renata Cifkova[41,42] ; Martha Daviglus[43] ; Graciela Delgado[44] ; Katalin Dittrich[45] ; Todd L. Edwards [46,47] ; Karlhans Endlich [6,48] ; J. Michael Gaziano[49] ; Ayush Giri [50,51] ; Franco Giulianini[35] ; Scott D. Gordon [52] ; Daniel F. Gudbjartsson[53,54] ; Stein Hallan[55,56] ; Pavel Hamet [57,58] ; Catharina A. Hartman [59] ; Caroline Hayward [25] ; Iris M. Heid[8] ; Jacklyn N. Hellwege [46,47,60] ; Bernd Holleczek[26] ; Hilma Holm [53] ; Nina Hutri-Kähönen[61] ; Kristian Hveem[19] ; Berend Isermann [2,62] ; Jost B. Jonas [63,64,65,66] ; Peter K. Joshi[33] ; Yoichiro Kamatani [17,67] ; Masahiro Kanai [17,68,69] ; Mika Kastarinen[70] ; Chiea Chuen Khor [71,72] ; Wieland Kiess[2,45] ; Marcus E. Kleber [44,73] ; Antje Körner [2,45,74] ; Peter Kovacs [75] ; Alena Krajcoviechova[41] ; Holly Kramer [76,77] ; Bernhard K. Krämer [44] ; Mikko Kuokkanen [78,79,80] ; Mika Kähönen[81,82] ; Leslie A. Lange[83] ; James P. Lash [84] ; Terho Lehtimäki [85,86] ; Hengtong Li[40] ; Bridget M. Lin[31] ; Jianjun Liu [71,87] ; Markus Loeffler[1,2] ; Leo-Pekka Lyytikäinen [85,86] ; Patrik K. E. Magnusson [38] ; Nicholas G. Martin [52] ; Koichi Matsuda[88] ; Yuri Milaneschi [89] ; Pashupati P. Mishra[85,86] ; Nina Mononen[85,86] ; Grant W. Montgomery [90] ; Dennis O. Mook-Kanamori[91,92] ; Josyf C. Mychaleckyj [93] ; Winfried März[44,94,95] ; Matthias Nauck [6,96] ; Kjell Nikus[97,98] ; Ilja M. Nolte [99] ; Raymond Noordam [100] ; Yukinori Okada [101,102,103] ; Isleifur Olafsson[104] ; Albertine J. Oldehinkel [59] ; Brenda W. J. H. Penninx[89] ; Markus Perola[78,79] ; Nicola Pirastu [33,105] ; Ozren Polasek [106] ; David J. Porteous [32] ; Tanja Poulain[2,45] ; Bruce M. Psaty[107] ; Ton J. Rabelink [108,109] ; Laura M. Raffield [110] ; Olli T. Raitakari[111,112,113] ; Humaira Rasheed [19,28,114] ; Dermot F. Reilly [115] ; Kenneth M. Rice [24] ; Anne Richmond[25] ; Paul M. Ridker[35,36] ; Jerome I. Rotter [116] ; Igor Rudan [33] ; Charumathi Sabanayagam[37,39] ; Veikko Salomaa [78] ; Neil Schneiderman[117] ; Ben Schöttker [26,27] ; Mario Sims[118] ; Harold Snieder [99] ; Klaus J. Stark [8] ; Kari Stefansson [53,119] ; Hannah Stocker [26,27] ; Michael Stumvoll [75] ; Patrick Sulem [53] ; Gardar Sveinbjornsson[53] ; Per O. Svensson [120,121] ; E-Shyong Tai [13,87,122] ; Kent D. Taylor [116] ; Bamidele O. Tayo[76] ; Andrej Teren[2,123] ; Yih-Chung Tham[37,40] ; Joachim Thiery[2,62] ; Chris H. L. Thio [99] ; Laurent F. Thomas [19,124,125,126] ; Johanne Tremblay[57] ; Anke Tönjes[75] ; Peter J. van der Most [99] ; Veronique Vitart[25] ; Uwe Völker [6,127] ; Ya Xing Wang [64] ; Chaolong Wang [71,128] ; Wen Bin Wei[129] ; John B. Whitfield [52] ; Sarah H. Wild [130] ; James F. Wilson [25,33] ; Thomas W. Winkler [8] ; Tien-Yin Wong [37,39,131] ; Mark Woodward[34,132] ; Xueling Sim [13] ; Audrey Y. Chu[133] ; Mary F. Feitosa [15] ; Unnur Thorsteinsdottir[53,119] ; Adriana M. Hung [46,134] ; Alexander Teumer [5,6,7,135] ; Nora Franceschini [136] ; Afshin Parsa[137] ; Anna Köttgen [3,138] ; Pascal Schlosser [3,138] ; Cristian Pattaro [139] ;
机构： [1]Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany [2]LIFE Research Center for Civilization Diseases,University of Leipzig, Leipzig, Germany [3]Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and MedicalCenter–University of Freiburg, Freiburg, Germany [4]Department of Medicine IV - Nephrology and Primary Care, Faculty of Medicine and Medical Center,University of Freiburg, Freiburg, Germany [5]Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany [6]DZHK (German Centerfor Cardiovascular Research), partner site Greifswald, Greifswald, Germany [7]Department of Psychiatry and Psychotherapy, University Medicine Greifswald,Greifswald, Germany [8]Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany [9]Department of Nephrology, UniversityHospital Regensburg, Regensburg, Germany [10]Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, UT, USA [11]Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA [12]Division of Nephrology,Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA [13]Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore [14]Institute for Maternal and Child Health, IRCCS ‘Burlo Garofolo’, Trieste, Italy [15]Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St.Louis, MO, USA [16]Institute of Genetics andBiophysics ‘Adriano Buzzati-Traverso’-CNR, Naples, Italy [17]Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS),Yokohama, Japan [18]Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan [19]K.G.Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health, Norwegian University of Science andTechnology, Trondheim, Norway [20]Department of Endocrinology, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway [21]Division ofNephrology, University of Washington, Seattle, WA, USA [22]Kidney Research Institute, University of Washington, Seattle, WA, USA [23]Cardiovascular HealthResearch Unit, Department of Medicine, University of Washington, Seattle, WA, USA [24]Department of Biostatistics, University of Washington, Seattle,WA, USA [25]Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK [26]Division ofClinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany [27]Network Aging Research, Heidelberg Uni-versity, Heidelberg, Germany [28]MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK [29]Clinic of Thoracic and Occupational Medicine, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway [30]Institute of Clinical Chemistry andLaboratory Medicine, University Hospital Regensburg, Regensburg, Germany [31]Department of Biostatistics, Gillings School of Global Public Health, Uni-versity of North Carolina at Chapel Hill, Chapel Hill, NC, USA [32]Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University ofEdinburgh, Edinburgh EH4 2XU, UK [33]Centre for Global Health, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland [34]TheGeorge Institute for Global Health, University of New South Wales, Sydney, NSW, Australia [35]Division of Preventive Medicine, Brigham and Women’s Hospital,Boston, MA, USA [36]Harvard Medical School, Boston, MA, USA [37]Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore [38]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden [39]Ophthalmology and Visual Sciences Academic ClinicalProgram (Eye ACP), Duke-NUS Medical School, Singapore, Singapore [40]Department of Ophthalmology, Yong Loo Lin School of Medicine, National Universityof Singapore and National University Health System, Singapore, Singapore [41]Center for Cardiovascular Prevention, Charles University in Prague, First Facultyof Medicine and Thomayer University Hospital, Prague, Czech Republic [42]Department of Medicine II, Charles University in Prague, First Faculty of Medicine,Prague, Czech Republic [43]Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA [44]Vth Department of Medicine(Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany [45]University Hospital for Children and Adolescents, Pediatric Research Unit, Medical Faculty, University Medical Center, University of Leipzig,Leipzig, Germany [46]Department of Veteran’s Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA [47]Division ofEpidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA [48]Department of Anatomyand Cell Biology, University Medicine Greifswald, Greifswald, Germany [49]Massachusetts Veterans Epidemiology Research and Information Center, VACooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA [50]Division of Quantitative Sciences, Department of Obstetrics & Gynecology,Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville,TN, USA [51]Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA [52]QIMRBerghofer Medical Research Institute, Brisbane, QLD, Australia [53]deCODE Genetics/Amgen, Inc.,Reykjavik, Iceland [54]Iceland School of Engineering andNatural Sciences, University of Iceland, Reykjavik, Iceland [55]Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science andTechnology, Trondheim, Norway [56]Department of Nephrology, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway [57]Montreal UniversityHospital Research Center, CHUM, Montréal, QC, Canada [58]Medpharmgene, Montreal, QC, Canada [59]Interdisciplinary Centre Psychopathology and Emotionregulation (ICPE), Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands [60]VanderbiltGenetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA [61]Tampere Centre for Skills Training and Simulation, Faculty of Medicine andHealth Technology, Tampere University, Tampere, Finland [62]Institute for Laboratory Medicine, University of Leipzig, Leipzig, Germany [63]Department ofOphthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany [64]Beijing Institute of Ophthalmology, Key Laboratory of Oph-thalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China [65]Institute of Molecular and Clinical Ophthalmology,Basel, Switzerland [66]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany [67]Laboratory of Complex Trait Genomics, Department of Compu-tational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan [68]Program in Medical and PopulationGenetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA [69]Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA [70]Finnish Medicines Agency, Kuopio, Finland [71]Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore [72]Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System,Singapore, Singapore [73]SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany [74]Helmholtz Institute for Metabolic, Obesity and Vascular Research(HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany [75]Department of Medicine,University of Leipzig, Leipzig, Germany [76]Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA [77]Division of Nephrology andHypertension, Loyola University Chicago, Chicago, IL, USA [78]Finnish Institute for Health and Welfare, Helsinki, Finland [79]Research Program for Clinical andMolecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland [80]Department of Human Genetics and South Texas Diabetes and ObesityInstitute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA [81]Department of Clinical Physiology, Tampere University Hospital,Tampere, Finland [82]Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology,Tampere University, Tampere, Finland [83]Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA [84]Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA [85]Department of ClinicalChemistry, Fimlab Laboratories, and The Wellbeing Services County of Pirkanmaa, Tampere, Finland [86]Department of Clinical Chemistry, Finnish Cardio-vascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland [87]Department of Medicine, Yong LooLin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore [88]Laboratory of Clinical GenomeSequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan [89]Department of Psychiatry, Amsterdam Public Health andAmsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, the Netherlands [90]University of Queensland, Brisbane,QLD, Australia [91]Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands [92]Department of Public Health and PrimaryCare, Leiden University Medical Center, Leiden, the Netherlands [93]Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville,VA, USA [94]Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria [95]Synlab Academy, Synlab HoldingDeutschland GmbH, Augsburg, Germany [96]Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany [97]Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland [98]Department of Cardiology, Finnish Cardiovascular ResearchCenter - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland [99]Department of Epidemiology, University of Gro-ningen, University Medical Center Groningen, Groningen, the Netherlands [100]Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands [101]Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences (IMS),Yokohama, Japan [102]Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan [103]Department of Genome Informatics,Graduate School of Medicine, the University of Tokyo, Tokyo, Japan [104]Department of Clinical Biochemistry, Landspitali University Hospital,Reykjavik, Iceland [105]Biostatistics Unit – Population and Medical Genomics Programme, Genomics Research Centre, Human Technopole Palazzo Italia, VialeRita Levi‑Montalcini, 1, 20157 Milan, Italy [106]University of Split Medical School, Split, Croatia [107]Cardiovascular Health Research Unit, Department of Medicine,Department of Epidemiology, Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA [108]Department of InternalMedicine, Section of Nephrology, Leiden University Medical Center, Leiden, the Netherlands [109]Einthoven Laboratory of Experimental Vascular Research,Leiden University Medical Center, Leiden, the Netherlands [110]Department of Genetics, University of North Carolina, Chapel Hill, NC, USA [111]Centre forPopulation Health Research, University of Turku and Turku University Hospital, Turku, Finland [112]Department of Clinical Physiology and Nuclear Medicine,Turku University Hospital, Turku, Finland [113]Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland [114]Division of Medicine and Laboratory Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway [115]Janssen Pharmaceuticals Inc., Titusville, NJ 08560,USA [116]The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation atHarbor-UCLA Medical Center, Torrance, CA, USA [117]Department of Psychology, University of Miami, Coral Gables, FL, USA [118]Department of Social Medicine,Population and Public Health, University of California at Riverside School of Medicine, Riverside, CA, USA [119]Faculty of Medicine, School of Health Sciences,University of Iceland, Reykjavik, Iceland [120]Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden [121]Department of Cardiology, Södersjukhuset, Stockholm, Sweden [122]Duke-NUS Medical School, Singapore, Singapore [123]Department of Cardiology andIntensive Care Medicine, University Hospital OWL of Bielefeld University, Campus Klinikum Bielefeld, Teutoburger Straße 50, 33604 Bielefeld, Germany [124]Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway [125]BioCore - Bioinformatics CoreFacility, Norwegian University of Science and Technology, Trondheim, Norway [126]Clinic of Laboratory Medicine, St.Olavs Hospital, Trondheim UniversityHospital, Trondheim, Norway [127]Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany [128]Schoolof Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [129]Beijing Tongren Eye Center, Beijing TongrenHospital, Capital Medical University, Beijing, China [130]Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland [131]TsinghuaMedicine, Tsinghua University, Beijing, China [132]The George Institute for Global Health, School of Public Health, Imperial College London, London, UK [133]Genetics, Merck & Co., Inc, Kenilworth, NJ, USA [134]Vanderbilt University Medical Center, Division of Nephrology & Hypertension, Nashville, TN, USA [135]Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland [136]Department of Epidemiology,Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [137]Division of Kidney, Urologic and HematologicDiseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA [138]Department of Epidemiology,Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA [139]Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck),Bolzano, Italy
出处：
DOI： 10.1038/s41467-024-44709-1
ISSN：

摘要：
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research.© 2024. The Author(s).

基金：
Open Access funding enabled and organized by Projekt DEAL
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
JCR分区：
出版当年[2022]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany [2]LIFE Research Center for Civilization Diseases,University of Leipzig, Leipzig, Germany
共同第一作者：
通讯作者：
通讯机构： [1]Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany [2]LIFE Research Center for Civilization Diseases,University of Leipzig, Leipzig, Germany
推荐引用方式(GB/T 7714)：
Markus Scholz,Katrin Horn,Janne Pott,et al.X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements[J].NATURE COMMUNICATIONS.2024,15(1):586.doi:10.1038/s41467-024-44709-1.
APA：
Markus Scholz,Katrin Horn,Janne Pott,Matthias Wuttke,Andreas Kühnapfel...&Cristian Pattaro.(2024).X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.NATURE COMMUNICATIONS,15,(1)
MLA：
Markus Scholz,et al."X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements".NATURE COMMUNICATIONS 15..1(2024):586

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