高级检索
当前位置: 首页 > 详情页

Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Xiamen Universityeaffiliated Xiamen Eye Center,Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University [2]Department of Ophthalmology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen [3]Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang [4]Department of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen [5]the Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China
出处:
ISSN:

摘要:
Sleep deprivation (SD) is a global public health burden, and has a detrimental role in the nervous system. Retina is an important part of the central nervous system; however, whether SD affects retinal structures and functions remains largely unknown. Herein, chronic SD mouse model indicated that loss of sleep for 4 months could result in reductions in the visual functions, but without obvious morphologic changes of the retina. Ultrastructural analysis by transmission electron microscope revealed the deterioration of mitochondria, which was accompanied with the decrease of multiple mitochondrial proteins in the retina. Mechanistically, oxidative stress was provoked by chronic SD, which could be ameliorated after rest, and thus restore retinal homeostasis. Moreover, the supplementation of two antioxidants, α-lipoic acid and N-acetyl-l-cysteine, could reduce retinal reactive oxygen species, repair damaged mitochondria, and, as a result, improve the retinal functions. Overall, this work demonstrated the essential roles of sleep in maintaining the integrity and health of the retina. More importantly, it points towards supplementation of antioxidants as an effective intervention strategy for people experiencing sleep shortages.Copyright © 2024 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2023]版:
大类 | 2 区 医学
小类 | 2 区 病理学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 病理学
JCR分区:
出版当年[2022]版:
Q1 PATHOLOGY
最新[2023]版:
Q1 PATHOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者:
第一作者机构: [1]Xiamen Universityeaffiliated Xiamen Eye Center,Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University [2]Department of Ophthalmology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen
共同第一作者:
通讯作者:
通讯机构: [1]Xiamen Universityeaffiliated Xiamen Eye Center,Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University [3]Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang [4]Department of Ophthalmology, Xiang’an Hospital of Xiamen University, Xiamen [*1]Eye Institute of Xiamen University, Xiang’an Hospital of Xiamen University, Medical College of Xiamen University, 401, Chengyi Bldg., Xiang-an campus of Xiamen University, S. Xiang-an Rd., Xiamen, Fujian 361102, China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:21169 今日访问量:0 总访问量:1219 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持:重庆聚合科技有限公司 地址:北京市东城区东交民巷1号(100730)