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Impact of pretreatment body mass index on the survival of head and neck cancer patients

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机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University , Key Laboratory of Otolaryngology Head and Neck Surgery of the Ministry of Education, Beijing, China. [2]Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [3]Department of Otolaryngology, The First Affiliated Hospital of Soochow University, Suzhou, China. [4]Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [5]Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, Texas, USA. [6]Division of Epidemiology, The University of Texas School of Public Health, Houston, Texas, USA.

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关键词： body mass index HPV oropharyngeal cancer squamous cell carcinoma of head and neck survival

摘要：

Differences in pretreatment body mass index (BMI) have been associated with survival in squamous cell carcinoma of head and neck (SCCHN). We examined effects of BMI on survival in SCCHN patients after stratifying patients by tumor human papillomavirus (HPV) status and subsite.Totally 2204 SCCHN patients in a prospective study were included in this secondary analysis. Multivariable Cox models were used to evaluate associations between pretreatment BMI and overall survival, disease-specific survival, and disease-free survival.BMI was significantly higher among patients with HPV-positive tumors than HPV-negative tumors. BMI >25 kg/m2 was associated with improved survival, while BMI <18.5 kg/m2 was associated with reduced survival, particularly in patients with HPV-positive oropharyngeal cancer tumors.This exploratory analysis suggests that pretreatment BMI could be an independent prognostic factor of survival outcomes in SCCHN patients, particularly in patients with HPV-positive oropharyngeal cancer tumors. Further prospective investigations are warranted.© 2024 Wiley Periodicals LLC.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区耳鼻喉科学 3 区外科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区耳鼻喉科学 3 区外科

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出版当年[2022]版：

Q1 OTORHINOLARYNGOLOGY Q2 SURGERY

最新[2023]版：

Q1 OTORHINOLARYNGOLOGY Q1 SURGERY Q2 SURGERY

影响因子： 2.4 最新[2023版] 2.8 最新五年平均 2.9 出版当年[2022版] 2.9 出版当年五年平均 3.821 出版前一年[2021版] 2.4 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University , Key Laboratory of Otolaryngology Head and Neck Surgery of the Ministry of Education, Beijing, China. [2]Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

通讯作者：

通讯机构： [2]Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [6]Division of Epidemiology, The University of Texas School of Public Health, Houston, Texas, USA. [*1]Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA [*2]Department of Head and Neck Surgery Director of Clinical Research, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

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Impact of pretreatment body mass index on the survival of head and neck cancer patients

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