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Preoperative Attention/Memory Problem Affects the Quality of Life of Parkinson's Disease Patients after Deep Brain Stimulation: A Cohort Study

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机构： [1]Department of Nursing, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China. [2]Public Health Department, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Institute of Health Informatics, University College London, London, UK. [4]Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up.Ninety-three patients diagnosed with Parkinson's disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included in this study. Demographic information was gathered through a self-designed questionnaire. The severity of both motor and non-motor symptoms, along with the quality of life (QoL), was assessed using the Unified Parkinson's Disease Rating Scale-III (UPDRS-III), Nonmotor Symptoms Scale (NMSS), and 8-item Parkinson's Disease Questionnaire (PDQ-8), respectively.Significant differences were observed in the UPDRS-III score, NMSS summary index (SI), and subscores of six domains (sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, urinary, and sexual function) between the baseline and the 6- and 12-month follow-ups. The correlation analysis revealed positive correlations between the preoperative NMSS SI and subscores of seven domains (cardiovascular, sleep/fatigue, mood/cognition, perceptual problems/hallucinations, attention/memory, gastrointestinal, and urinary) and ΔPDQ-8. Moreover, the preoperative PDQ-8 SI (β = 0.869, P < 0.001) and the preoperative attention/memory subscore (β = -0.154, P = 0.026) were predictive of the postsurgery improvement in quality of life (QoL).Deep brain stimulation (DBS) led to an improvement in the patients' nonmotor symptoms (NMS) at the 1-year follow-up, along with a correlation observed between NMS and the patients' quality of life (QoL). Notably, the severity of preoperative attention/memory problems emerged as the most significant predictor of NMS influencing the QoL outcome after STN-DBS at the 1-year follow-up.Copyright © 2024 Ying Gao et al.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

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出版当年[2022]版：

Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q3 CLINICAL NEUROLOGY

影响因子： 2.1 最新[2023版] 2.8 最新五年平均 3.2 出版当年[2022版] 3.2 出版当年五年平均 3.17 出版前一年[2021版] 2.1 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Nursing, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China. [2]Public Health Department, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Institute of Health Informatics, University College London, London, UK.

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通讯作者：

通讯机构： [1]Department of Nursing, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China. [4]Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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