机构：[1]Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.[2]Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.[3]Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.[4]Institute of Translational Genomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[5]Institute of Translational Genomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[6]Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.[7]British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.[8]Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.[9]Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.[10]Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.[11]Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.[12]Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[13]Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[14]Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.[15]Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.[16]TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.[17]William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.[18]Graduate School of Experimental Medicine, Technical University of Munich, Munich, Germany.[19]Munich School for Data Science, Helmholtz Munich, Neuherberg, Germany.[20]Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.[21]Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.[22]Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.[23]Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.[24]Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.[25]Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.[26]Nuffield Department of Population Health, University of Oxford, Oxford, UK.[27]Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.[28]Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.[29]Department of Epidemiology and Biostatistics, Imperial College London, London, UK.[30]Department of Cardiology, Ealing Hospital, London NorthWest Healthcare NHS Trust, London, UK.[31]Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea.[32]Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[33]Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.[34]Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[35]Department of Medicine, McMaster University, Hamilton, Ontario, Canada.[36]Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.[37]Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.[38]MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.[39]Department of Health Data Science, University of Liverpool, Liverpool, UK.[40]Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.[41]Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.[42]Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada.[43]Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.[44]Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.[45]Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.[46]deCODE Genetics, Amgen, Reykjavik, Iceland.[47]Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[48]Department of Biostatistics, Harvard University, Boston, MA, USA.[49]Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.[50]Department of Medicine, Harvard University, Boston, MA, USA.[51]Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.[52]Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.[53]German Center for Diabetes Research (DZD), Neuherberg, Germany.[54]Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[55]Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.[56]Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.[57]Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.[58]Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.[59]Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.[60]Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.[61]Institute for Population and Precision Health (IPPH), Biological Sciences Division, University of Chicago, Chicago, IL, USA.[62]Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.[63]Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.[64]Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.[65]Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Chinese University of Hong Kong, Hong Kong, China.[66]Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea.[67]Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.[68]Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.[69]Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[70]Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.[71]Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.[72]Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.[73]Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.[74]Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.[75]Division of Academics, Ochsner Health, New Orleans, LA, USA.[76]Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA.[77]Department of Research and Evaluation, Division of Biostatistics Research, Kaiser Permanente of Southern California, Pasadena, CA, USA.[78]Department of Biomedical Science, Hallym University, Chuncheon, South Korea.[79]Harvard Medical School, Boston, MA, USA.[80]Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK.[81]Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.[82]Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran.[83]Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA.[84]Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden.[85]Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[86]Unidad de Investigacion en Enfermedades Metabolicas and Departamento de Endocrinologia y Metabolismo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.[87]Steno Diabetes Center Copenhagen, Herlev, Denmark.[88]Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark.[89]Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.[90]Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.[91]Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.[92]Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark.[93]Department of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of USC, Los Angeles, CA, USA.[94]Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.[95]British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.[96]Health Data Research UK Cambridge, Wellcome Genome Campus, University of Cambridge, Hinxton, UK.[97]National Institute for Health and Care Research (NIHR) Blood and Transplant Unit (BTRU) in Donor Health and Behaviour, Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.[98]Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, France.[99]University of Lille, Lille, France.[100]Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.[101]Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong, China.[102]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.[103]Exeter Centre of Excellence in Diabetes (ExCEeD), Exeter Medical School, University of Exeter, Exeter, UK.[104]Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.[105]Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.[106]Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.[107]Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.[108]Department of Medicine, University of Vermont, Colchester, VT, USA.[109]Section of Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.[110]Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.[111]Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece.[112]Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.[113]Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[114]Department of Nephrology and Medical Intensive Care Medicine, Charite-Universitatsmedizin Berlin, Berlin, Germany.[115]Department of Nephrology and Hypertension, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany.[116]Department of Biostatistics, University of Washington, Seattle, WA, USA.[117]California Pacific Medical Center Research Institute, San Francisco, CA, USA.[118]Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.[119]Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia.[120]Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.[121]Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.[122]Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.[123]Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.[124]Department of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.[125]Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.[126]Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Mexico City, Mexico.[127]Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.[128]Genomics and Computational Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[129]Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.[130]Folkhalsan Research Center, Helsinki, Finland.[131]University of Exeter Medical School, University of Exeter, Exeter, UK.[132]Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Dusseldorf, Germany.[133]Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich Heine University Dusseldorf, Dusseldorf, Germany.[134]Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.[135]Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.[136]Department of Internal Medicine, Diabetes and Metabolism Research Center, Ohio State University Wexner Medical Center, Columbus, OH, USA.[137]Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA.[138]Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China.[139]Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.[140]School of Medicine, National Defense Medical Center, Taipei, Taiwan.[141]Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea.[142]Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.[143]School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.[144]Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.[145]University of Chicago Research Bangladesh, Dhaka, Bangladesh.[146]Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.[147]Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.[148]Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[149]Faculty of Medicine, Aalborg University, Aalborg, Denmark.[150]Department of Clinical Diabetes, Endocrinology and Metabolism, Department of Translational Research and Cellular Therapeutics, City of Hope, Duarte, CA, USA.[151]Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.[152]Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.[153]Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.[154]Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.[155]Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.[156]Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.[157]Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea.[158]Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.[159]Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.[160]Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.[161]VA Salt Lake City Health Care System, Salt Lake City, UT, USA.[162]Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.[163]Soochunhyang Institute of Medi-bio Science and Division of Endocrinology, Department of Internal Medicine, Soochunhyang University College of Medicine, Cheonan, South Korea.[164]Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.[165]USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.[166]Department of Medicine, Harvard Medical School, Boston, MA, USA.[167]Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.[168]Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.[169]Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China.[170]Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.[171]Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.[172]Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.[173]Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.[174]Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.[175]Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.[176]Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.[177]McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA.[178]Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of Medicine, St Louis, MO, USA.[179]Regeneron Genetics Center, Tarrytown, NY, USA.[180]Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.[181]Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmo, Sweden.[182]Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.[183]Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.[184]Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan.[185]Dromokaiteio Psychiatric Hospital, National and Kapodistrian University of Athens, Athens, Greece.[186]Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.[187]Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.[188]Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[189]Institute of Human Genetics, Technical University Munich, Munich, Germany.[190]German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.[191]Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.[192]Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY, USA.[193]Data Tecnica International, Glen Echo, MD, USA.[194]Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.[195]Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.[196]Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan.[197]Instituto Nacional de Medicina Genomica, Mexico City, Mexico.[198]Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.[199]Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.[200]Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.[201]Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.[202]Academy of Scientific and Innovative Research, CSIR-Human Resource Development Campus, Ghaziabad, India.[203]Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.[204]Fred Hutchinson Cancer Research Center, Seattle, WA, USA.[205]Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.[206]Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.[207]School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.[208]Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.[209]Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[210]Institute for Medical Biostatistics, Epidemiology, and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.[211]Chair of Genetic Epidemiology, Institute of Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine, Ludwig-Maximilians-Universitat Munchen, Munich, Germany.[212]Faculty of Medicine, University of Iceland, Reykjavik, Iceland.[213]Faculty of Medicine, Macau University of Science and Technology, Macau, China.[214]Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan.[215]Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.[216]National School of Public Health, Madrid, Spain.[217]Department of Public Health, University of Helsinki, Helsinki, Finland.[218]Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.[219]Unidad de Biologia Molecular y Medicina Genomica, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.[220]Departamento de Medicina Genomica y Toxiologia Ambiental, Instituto de Investigaciones Biomedicas, UNAM, Mexico City, Mexico.[221]Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.[222]Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.[223]Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.[224]Department of Clinical Chemistry, Laboratory of Genetic Metabolic Disease, Amsterdam University Medical Center, Amsterdam, The Netherlands.[225]Southern California Eye Institute, CHA Hollywood Presbyterian Hospital, Los Angeles, CA, USA.[226]Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.[227]Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.[228]Department of Public Health, Aarhus University, Aarhus, Denmark.[229]Danish Diabetes Academy, Odense, Denmark.[230]Diabetology Research Centre, King Edward Memorial Hospital and Research Centre, Pune, India.[231]Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.[232]Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.[233]Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.[234]Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.[235]Department of Pediatrics, Division of Genetic and Genomic Medicine, UCI Irvine School of Medicine, Irvine, CA, USA.[236]Department of Anti-Aging Medicine, Ehime University Graduate School of Medicine, Touon, Japan.[237]Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.[238]Department of Medical Sciences, Uppsala University, Uppsala, Sweden.[239]Institute of Molecular Medicine, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.[240]Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.[241]Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.[242]Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.[243]Department of Epidemiology, University of Washington, Seattle, WA, USA.[244]Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.[245]Beijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China.研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[246]Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.[247]Kurume University School of Medicine, Kurume, Japan.[248]Department of Medicine, McGill University, Montreal, Quebec, Canada.[249]Department of Human Genetics, McGill University, Montreal, Quebec, Canada.[250]Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.[251]Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.[252]Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.[253]Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.[254]Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.[255]Department of Anthropology, Northwestern University, Evanston, IL, USA.[256]Department of Endocrinology, Helsinki University Hospital, Helsinki, Finland.[257]Science and Engineering Research Board (SERB), Department of Science and Technology, Ministry of Science and Technology, Government of India, New Delhi, India.[258]Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.[259]Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.[260]Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.[261]Netherlands Heart Institute, Utrecht, The Netherlands.[262]Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.[263]Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany.[264]Duke-NUS Medical School, Singapore, Singapore.[265]Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.[266]Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.[267]Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.[268]Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.[269]Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.[270]Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, University of Dundee, Dundee, UK.[271]Imperial College Healthcare NHS Trust, Imperial College London, London, UK.[272]MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.[273]National Heart and Lung Institute, Imperial College London, London, UK.[274]Department of Medicine, Brown University Alpert School of Medicine, Providence, RI, USA.[275]Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.[276]Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.[277]Center for Non-Communicable Diseases, Karachi, Pakistan.[278]Computational Medicine, Berlin Institute of Health at Charite-Universitatsmedizin, Berlin, Germany.[279]Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.[280]Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.[281]The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, NY, USA.[282]Division of Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[283]Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[284]Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[285]Center for Precision Medicine, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA.[286]Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[287]Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.[288]Blizard Institute, Queen Mary University of London, London, UK.[289]Institute for Population Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.[290]All of Us Research Program, National Institutes of Health, Bethesda, MD, USA.[291]Toranomon Hospital, Tokyo, Japan.[292]Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.[293]Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.[294]VA Palo Alto Health Care System, Palo Alto, CA, USA.[295]Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.[296]Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[297]Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.[298]Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.[299]Genentech, South San Francisco, CA, USA.[300]Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.[301]Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[302]Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.[303]Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[304]Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[305]Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[306]Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.[307]Institute of Translational Genomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[308]Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.[309]Institute of Translational Genomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[310]TUM School of Medicine and Health, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany.
Central analyses were supported by the Japan Agency for Medical
Research and Development (JP21km0405213, JP20km0405202 and JP21tm0424218), NHGRI
(HG011723), the American Diabetes Association Innovative and a Clinical Translational Award
(1-19-ICTS-068), the European Union’s Horizon 2020 research and innovation programme
under grant agreement no. 101017802 (OPTOMICS), American Heart Association Postdoctoral
Fellowships (15POST24470131 and 17POST33650016), the American Diabetes Association
(11-22-JDFPM-06), Corporal Michael J Crescenz VA Medical Center Research, NIDDK (DK126194
and DK105535), Versus Arthritis (21754), NIHR Manchester Biomedical Research Centre
(NIHR203308) and the MRC (MR/W029626/1).
第一作者机构：[1]Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.[2]Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.[3]Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
共同第一作者：
通讯作者：
通讯机构：[302]Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.[303]Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[304]Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[305]Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.[306]Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.[307]Institute of Translational Genomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[308]Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.[309]Institute of Translational Genomics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.[310]TUM School of Medicine and Health, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany.
推荐引用方式(GB/T 7714)：
Suzuki Ken,Hatzikotoulas Konstantinos,Southam Lorraine,et al.Genetic drivers of heterogeneity in type 2 diabetes pathophysiology[J].NATURE.2024,627(8003):doi:10.1038/s41586-024-07019-6.
APA：
Suzuki Ken,Hatzikotoulas Konstantinos,Southam Lorraine,Taylor Henry J,Yin Xianyong...&Zeggini Eleftheria.(2024).Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.NATURE,627,(8003)
MLA：
Suzuki Ken,et al."Genetic drivers of heterogeneity in type 2 diabetes pathophysiology".NATURE 627..8003(2024)
综合性期刊