详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells

4| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：

机构： [1]Hongqiao International Institute of Medicine, Tongren Hospital & Shanghai Institute of Immunology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. [2]Department of Immunology, Key Laboratory of Immune Microenvironment and Disease, the School of Basic Medicine, Nanjing Medical University, Nanjing 211166, China. [3]Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. [4]Clinical Medical College, Hebei University of Engineering, Handan 056038, Hebei, China [5]Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microecological Metabolism Regulation, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China [6]Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China

出处：

DOI：

ISSN：

摘要：

RNA splicing is involved in cancer initiation and progression, but how it influences host antitumor immunity in the metabolically abnormal tumor microenvironment (TME) remains unclear. Here, we demonstrate that lactate modulates Foxp3-dependent RNA splicing to maintain the phenotypic and functional status of tumor-infiltrating regulatory T (Treg) cells via CTLA-4. RNA splicing in Treg cells was correlated with the Treg cell signatures in the TME. Ubiquitin-specific peptidase 39 (USP39), a component of the RNA splicing machinery, maintained RNA-splicing-mediated CTLA-4 expression to control Treg cell function. Mechanistically, lactate promoted USP39-mediated RNA splicing to facilitate CTLA-4 expression in a Foxp3-dependent manner. Moreover, the efficiency of CTLA-4 RNA splicing was increased in tumor-infiltrating Treg cells from patients with colorectal cancer. These findings highlight the immunological relevance of RNA splicing in Treg cells and provide important insights into the environmental mechanism governing CTLA-4 expression in Treg cells.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：

语种：

高被引：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 1 区

医学

小类 | 1 区免疫学

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区免疫学

JCR分区：

出版当年[2022]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 25.5 最新[2023版] 33.2 最新五年平均 32.4 出版当年[2022版] 36.3 出版当年五年平均 43.474 出版前一年[2021版] 25.5 出版后一年[2023版]

第一作者：

第一作者机构： [1]Hongqiao International Institute of Medicine, Tongren Hospital & Shanghai Institute of Immunology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

共同第一作者：

通讯作者：

通讯机构： [4]Clinical Medical College, Hebei University of Engineering, Handan 056038, Hebei, China [5]Central Laboratory, Hebei Collaborative Innovation Center of Tumor Microecological Metabolism Regulation, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China [6]Affiliated Hospital of Hebei Engineering University, Handan 056002, Hebei, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells $(function () { $("[data-toggle='tooltip']").tooltip(); });

文献详情

Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells