Cell Membrane-Camouflaged Chitosan-Polypyrrole Nanogels Co-Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer
机构：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.[2]Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.[3]Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200336, China.[4]CQM - Centro de Quimica da Madeira, Universidade da Madeira, Campus Universitario da Penteada, Funchal, 9020-105, Portugal.
The development of functional nanoplatforms to improve the chemotherapy outcome and inhibit distal cancer cell metastasis remains an extreme challenge in cancer management. In this work, we report a human-derived PC-3 cancer cell membrane-camouflaged chitosan-polypyrrole nanogel (CH-PPy NG) platform, which can be loaded with chemotherapeutic drug docetaxel (DTX) and RANK siRNA for targeted chemotherapy and gene silencing-mediated metastasis inhibition of late-stage prostate cancer in a mouse model. The prepared NGs with a size of 155.8 nm show good biocompatibility, pH-responsive drug release profile, and homologous targeting specificity to cancer cells, allowing for efficient and precise drug/gene co-delivery. Through in-vivo antitumor treatment in a xenografted PC-3 mouse tumor model, we show that such a CH-PPy NG-facilitated co-delivery system allows for effective chemotherapy to slow down the tumor growth rate, and effectively inhibits the metastasis of prostate cancer to the bone via downregulation of the RANK/RANKL signaling pathway. The created CH-PPy NGs may be utilized as a promising platform for enhanced chemotherapy and anti-metastasis treatment of prostate cancer. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
基金：
This research was financially sponsored by the National Natural Science Foundation of China
(52350710203 and U23A2096), the Science and Technology Commission of Shanghai Municipality
(21490711500, 23WZ2503300, 23520712500 and 20DZ2254900), and the Shanghai Education
Commission through the leading talent program. This project was also supported by Researchers
Supporting Project Number (RSPD2024R769), King Saud University, Riyadh, Saudi Arabia.
第一作者机构：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
通讯作者：
通讯机构：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.[4]CQM - Centro de Quimica da Madeira, Universidade da Madeira, Campus Universitario da Penteada, Funchal, 9020-105, Portugal.
推荐引用方式(GB/T 7714)：
Yu Qiuyu,Gao Yue,Dai Waicong,et al.Cell Membrane-Camouflaged Chitosan-Polypyrrole Nanogels Co-Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer[J].Advanced Healthcare Materials.2024,13(20):e2400114.doi:10.1002/adhm.202400114.
APA：
Yu Qiuyu,Gao Yue,Dai Waicong,Li Danni,Zhang Lu...&Cao Xueyan.(2024).Cell Membrane-Camouflaged Chitosan-Polypyrrole Nanogels Co-Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer.Advanced Healthcare Materials,13,(20)
MLA：
Yu Qiuyu,et al."Cell Membrane-Camouflaged Chitosan-Polypyrrole Nanogels Co-Deliver Drug and Gene for Targeted Chemotherapy and Bone Metastasis Inhibition of Prostate Cancer".Advanced Healthcare Materials 13..20(2024):e2400114
医学