The objective of this study was to assess the relationship between the triglyceride-glucose (TyG) index, a recently proposed marker of insulin resistance, and the occurrence of diabetic retinopathy (DR), a complication associated with cardiovascular risk. This systematic review and meta-analysis aimed to evaluate the association between the TyG index and DR. To achieve the objective of the meta-analysis, an extensive search was conducted on databases such as PubMed, Embase, and Web of Science to identify observational studies with longitudinal follow-up. Random-effects models were employed to combine the findings, taking into account the potential influence of heterogeneity. Twelve observational studies from 11 reports were included in the meta-analysis, which involved 16 259 patients with type 2 diabetes (T2D). Among them, 4302 (26.5%) were diagnosed as DR. Pooled results showed that a higher TyG index was associated with a higher risk of DR [odds ratio (OR) for the fourth versus the first quartile of TyG index: 1.91, 95% confidence interval (CI): 1.44 to 2.53, p<0.001; I2=72%]. Meta-analysis of TyG index analyzed in continuous variable showed consistent results (OR for per 1 unit increment of TyG index: 1.41, 95% CI: 1.08 to 1.86, p=0.01; I2=82%). Subgroup analysis showed that adjustment of HbA1c or the duration of diabetes did not significantly affect the results (p for subgroup difference all>0.05). In conclusion, a high TyG index was associated with the risk of DR in T2D patients.
基金:
Zhangjiakou Key research and Development Program project of China [2022-2221055D]
第一作者机构:[1]Shanghai Baoshan Dist Hosp Integrated Tradit Chine, Ophthalmol Dept, Shanghai, Peoples R China
通讯作者:
通讯机构:[2]Beijing Tongren Hosp CMU, Beijing Tongren Eye Ctr, Beijing, Peoples R China[3]Zhang Jiakou Aier Eye Hosp, 16 Jianshedong St, Zhang Jiakou, Peoples R China
推荐引用方式(GB/T 7714):
Yu Lanchu,Li Bingqing.Association Between Triglyceride-Glucose Index and Diabetic Retinopathy: A Meta-Analysis[J].HORMONE AND METABOLIC RESEARCH.2024,56(11):785-794.doi:10.1055/a-2279-7112.
APA:
Yu, Lanchu&Li, Bingqing.(2024).Association Between Triglyceride-Glucose Index and Diabetic Retinopathy: A Meta-Analysis.HORMONE AND METABOLIC RESEARCH,56,(11)
MLA:
Yu, Lanchu,et al."Association Between Triglyceride-Glucose Index and Diabetic Retinopathy: A Meta-Analysis".HORMONE AND METABOLIC RESEARCH 56..11(2024):785-794