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Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma

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收录情况： ◇ SCIE

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机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China [3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [5]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China [6]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China [7]Henan Academy of Innovations in Medical Science, Zhengzhou, Henan 450052, China

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摘要：

The axons of retinal ganglion cells (RGCs) form the optic nerve, transmitting visual information from the eye to the brain. Damage or loss of RGCs and their axons is the leading cause of visual functional defects in traumatic injury and degenerative diseases such as glaucoma. However, there are no effective clinical treatments for nerve damage in these neurodegenerative diseases. Here, we report that LIM homeodomain transcription factor Lhx2 promotes RGC survival and axon regeneration in multiple animal models mimicking glaucoma disease. Furthermore, following N-methyl-D-aspartate (NMDA)-induced excitotoxicity damage of RGCs, Lhx2 mitigates the loss of visual signal transduction. Mechanistic analysis revealed that overexpression of Lhx2 supports axon regeneration by systematically regulating the transcription of regeneration-related genes and inhibiting transcription of Semaphorin 3C (Sema3C). Collectively, our studies identify a critical role of Lhx2 in promoting RGC survival and axon regeneration, providing a promising neural repair strategy for glaucomatous neurodegeneration.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

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出版当年[2023]版：

大类 | 1 区

医学

小类 | 1 区医学：研究与实验 2 区细胞生物学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区医学：研究与实验 2 区细胞生物学

JCR分区：

出版当年[2022]版：

Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 CELL BIOLOGY

影响因子： 11.7 最新[2023版] 0 最新五年平均 14.3 出版当年[2022版] 14.3 出版当年五年平均 16.988 出版前一年[2021版] 11.7 出版后一年[2023版]

第一作者：

第一作者机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China [3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

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通讯作者：

通讯机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China [3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [5]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China [6]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China [7]Henan Academy of Innovations in Medical Science, Zhengzhou, Henan 450052, China

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