机构:[1]Department of Endocrinology, Capital Medical University, Beijing, China.[2]Department of Endocrinology, Beijing Tongren Hospital CMU, Beijing, China.临床科室内分泌科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing Obstetrics and Gynecology Hospital, Beijing, China.
Pregnancy requires metabolic adaptations in order to meet support fetal growth with nutrient availability. In this study, the influence of pregnancy on metabolically active organs (adipose tissues in particular) was investigated. Our results showed that maternal weight and adipose mass presented dynamic remodeling in the periparturient mice. Meanwhile, pregnancy mice displayed obvious glucose intolerance and insulin resistance in late pregnancy as compared to non-pregnancy, which were partially reversed at parturition. Further analysis revealed that different fat depots exhibited site-specific adaptions of morphology and functionality as pregnancy advanced. Brown and inguinal white adipose tissue (BAT and IngWAT) exhibited obviously decreased thermogenic activity; by contrast, gonadal white adipose tissue (GonWAT) displayed remarkably increased lipid mobilization. Notably, we found that mammary gland differentiation was enhanced in IngWAT, followed by BAT, but not in GonWAT. These result indicated that brown and white adipose tissues might synergistically play a crucial role in maintaining the maxicum of energy supply for mother and fetus, which facilitates the mammary duct luminal epithelium development as well as the growth and development of fetus. Accompanied with adipose adaptation, however, our results revealed that the liver and pancreas also displayed significant metabolic adaptability, which together tended to trigger the risk of maternal metabolic diseases. Importantly, pregnancy-dependent obesity in our mice model resembled the disturbed metabolic phenotypes of pregnant women such as hyperglyceridemia and hypercholesterolemia. Our findings in this study could provide valuable clues for better understanding the underlying mechanisms of metabolic maladaptation, and facilitate the development of the prevention and treatment of metabolic diseases.
第一作者机构:[1]Department of Endocrinology, Capital Medical University, Beijing, China.
通讯作者:
推荐引用方式(GB/T 7714):
Wei Gang,Zhu Juanjuan,Shen Feng-Jie,et al.Heterogeneous metabolic changes of brown and white adipose tissues are associated with metabolic adaptations in periparturient mice[J].Journal Of Molecular Endocrinology.2024,73(2):doi:10.1530/JME-24-0012.
APA:
Wei Gang,Zhu Juanjuan,Shen Feng-Jie,Xie Rong-Rong,Zhang Chen-Yang...&Yang Jin-Kui.(2024).Heterogeneous metabolic changes of brown and white adipose tissues are associated with metabolic adaptations in periparturient mice.Journal Of Molecular Endocrinology,73,(2)
MLA:
Wei Gang,et al."Heterogeneous metabolic changes of brown and white adipose tissues are associated with metabolic adaptations in periparturient mice".Journal Of Molecular Endocrinology 73..2(2024)