机构：[1]Institut Français de Myopie, Hôpital Fondation Rothschild, Paris, France[2]Singapore Eye Research Institute, Singapore[3]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany[4]Ufa Eye Research Institute, Bashkir State Medical University, Ufa, Russia[5]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology andVisual Sciences Key Laboratory, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[6]Department of Ophthalmology, University of Cologne, Cologne, Germany[7]Department of Ophthalmology, Medical Faculty Heidelberg, Heidelberg University Heidelberg, Germany
To examine the prevalence of Bruch's membrane defects (BMDs) and subretinal proliferations (SRPs) in highly myopic eyes with myopic macular atrophy (myopic macular degeneration [MMD] stage 4) and myopic patchy atrophies (MMD stage 3) in three ethnically different cohorts recruited in a population-based manner.The Ural Eye and Medical Study (UEMS) and Beijing Eye Study (BES) included individuals aged 40+ years, and the Ural Very Old Study (UVOS) examined individuals aged 85+ years. Main outcome measures were the prevalence of BMDs and SRPs.Among 5794 UEMS participants, 19 eyes had MMD stage 4, with 17 (89%) eyes showing a foveal BMD; two eyes could not fully be explored. All 19 eyes showed localized SRPs. Among 21 eyes with MMD stage 3, BMD and SRP prevalence was 9 of 21 (44%) and 7 of 21 (33%), respectively. Among 930 UVOS participants, 17 eyes had MMD stage 4, with 16 (94%) eyes showing foveal BMDs and SRPs; one eye could not be assessed. Among 18 eyes with MMD stage 3, BMD and SRP prevalence was 3 of 18 (17%) and 2 of 18 (11%), respectively. Among 3468 BES participants, 8 eyes had MMD stage 4, with all eyes showing foveal BMDs and SRPs. Among 14 eyes with MMD stage 3, BMD and SRP prevalence was 10 of 14 (71%) and 7 of 21 (33%), respectively.All eyes with assessable myopic macular atrophy showed foveal BMDs associated with SRPs, while patchy atrophies could be differentiated into those with BMDs and SRPs and those without BMDs and without SRPs. Independent of the MMD stage, the prevalences of BMDs and SRPs were highly significantly associated with each other.
第一作者机构：[1]Institut Français de Myopie, Hôpital Fondation Rothschild, Paris, France[2]Singapore Eye Research Institute, Singapore[3]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany[*1]Privatpraxis Prof Jonas und Dr Panda-Jonas, Adenauerplatz 2,Heidelberg 69115, Germany
通讯作者：
通讯机构：[1]Institut Français de Myopie, Hôpital Fondation Rothschild, Paris, France[2]Singapore Eye Research Institute, Singapore[3]Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany[*1]Privatpraxis Prof Jonas und Dr Panda-Jonas, Adenauerplatz 2,Heidelberg 69115, Germany
推荐引用方式(GB/T 7714)：
Jonas Jost B,Bikbov Mukharram M,Kazakbaeva Gyulli M,et al.Myopic Macular Atrophy in the Two-Continent Population-Based Study[J].Investigative Ophthalmology & Visual Science.2024,65(8):38.doi:10.1167/iovs.65.8.38.
APA：
Jonas Jost B,Bikbov Mukharram M,Kazakbaeva Gyulli M,Wang Ya Xing,Xu Jie...&Panda-Jonas Songhomitra.(2024).Myopic Macular Atrophy in the Two-Continent Population-Based Study.Investigative Ophthalmology & Visual Science,65,(8)
MLA：
Jonas Jost B,et al."Myopic Macular Atrophy in the Two-Continent Population-Based Study".Investigative Ophthalmology & Visual Science 65..8(2024):38
