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Projections from the ventral tegmental area to zona incerta regulate fear generalization in a mouse model of PTSD

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收录情况： ◇ SCIE

作者：
Tong Kun[1] * ; Wang Shuang[2] * ; Zhu Yi-Jie[3] * ; Chen Zhi-Peng[1] ; Jing Si-Qi[4] ;
机构： [1]Department of Anesthesia, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China [2]Department of Anesthesia, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, 269 Daxue Road, Xuzhou, Jiangsu 221000, China [3]Department of Anesthesia, The Nanjing Tongren Hospital, 2007 Jiyin Road, Nanjing, Jiangsu 211102, China [4]Jiangsu Province Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, Jiangsu 221004, China
出处：
DOI： 10.1016/j.brainresbull.2024.111079
ISSN：

关键词： Anxiety Fear generalization Glutamatergic neurons VTA ZI

摘要：
Generalized fear is a maladaptive behavior in which non-threatening stimuli elicit a fearful response. The ventral tegmental area (VTA) has been demonstrated to play important roles in fear response and fear memory generalization, but the precious neural circuit mechanism is still unclear. Here, we demonstrated that VTA-zona incerta (ZI) glutamatergic projection is involved in regulating high-intensity threatening training induced generalization and anxiety. Combining calcium signal recording and chemogentics, our work reveals that VTA glutamatergic neurons respond to closed arm entering in the model of PTSD. Inhibition of VTA glutamatergic neurons or the glutamatergic projection to ZI could both relieve fear generalization and anxiety. Together, our study proves the VTA - ZI glutamatergic circuit is involved in mediating fear generalization and anxiety, and provides a potential target for treating post-traumatic stress disorder.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
This project was supported by the National Natural Science Foundation of China Grant (No. 82401422(K.T.)), Open project from the Jiangsu Province key laboratory (XZSYSKF2023029(K.T.)), Talent introduction research start-up funds (2024203030(K.T.)), and Advanced Program of The Affiliated Hospital of Xuzhou Medical University (PYJH2024304(K.T.)).
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外文
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出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
JCR分区：
出版当年[2022]版：
Q2 NEUROSCIENCES
最新[2023]版：
Q2 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Anesthesia, The Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu 221002, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Tong Kun,Wang Shuang,Zhu Yi-Jie,et al.Projections from the ventral tegmental area to zona incerta regulate fear generalization in a mouse model of PTSD[J].Brain Research Bulletin.2024,217:111079.doi:10.1016/j.brainresbull.2024.111079.
APA：
Tong Kun,Wang Shuang,Zhu Yi-Jie,Chen Zhi-Peng&Jing Si-Qi.(2024).Projections from the ventral tegmental area to zona incerta regulate fear generalization in a mouse model of PTSD.Brain Research Bulletin,217,
MLA：
Tong Kun,et al."Projections from the ventral tegmental area to zona incerta regulate fear generalization in a mouse model of PTSD".Brain Research Bulletin 217.(2024):111079

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