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TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis

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收录情况： ◇ SCIE

作者：
Chen Zixuan[1] * ; Jia Xing[1] * ; Wang Zhou[1] * ; Cai Yuesong[3] ; Xu An[1] ; Han Chengtao[1] ; Cheng Sheng[2,*2] ; Liu Min[1,*1] ;
机构： [1]Department of Urology, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China [2]Hongqiao International Institute of Medicine, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China [3]College of Medicine, Yanbian University, Yanji 133002, China
出处：
DOI： 10.1016/j.cellsig.2024.111421
ISSN：

关键词： Clear cell renal cell carcinoma TRIB3 Ferroptosis Sunitinib Sensitivity

摘要：
Sunitinib resistance presents a significant challenge in the treatment of clear cell renal cell carcinoma (ccRCC). The role of TRIB3, a newly identified oncogene, in tumor drug resistance has been widely studied. However, the mechanism by which TRIB3 contributes to sunitinib resistance in ccRCC has not been previously explored. This study aimed to investigate the mechanism through which TRIB3 regulates ferroptosis to increase the susceptibility of ccRCC to sunitinib treatment. Bioinformatics analysis and experimental validation revealed that TRIB3 is significantly upregulated in ccRCC tissues and is associated with poor prognosis. Knockdown of TRIB3 using siRNA transfection inhibited the proliferation and migration of ccRCC cells and induced ferroptosis. Following sunitinib treatment, TRIB3 knockdown increased cell sensitivity to sunitinib, enhanced the suppressive impact of sunitinib, and augmented sunitinib-induced ferroptosis. This study demonstrated that TRIB3 knockdown induces ferroptosis by targeting the SLC7A11/GPX4 pathway and enhances therapeutic efficacy of sunitinib for ccRCC, providing new insights and potential strategies to overcome the challenge of sunitinib resistance in ccRCC.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：
This research was funded by grants from the National Natural Science Foundation of China (No. 82172809), Research Fund of Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine (No. TRKYRC-xx202205 and No. 2023DHYGJC-YBA04).
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 生物学
小类 | 3 区 细胞生物学
最新[2023]版：
大类 | 2 区 生物学
小类 | 3 区 细胞生物学
JCR分区：
出版当年[2022]版：
Q2 CELL BIOLOGY
最新[2023]版：
Q2 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Urology, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Urology, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China [2]Hongqiao International Institute of Medicine, Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China [*1]No.1111 Xian xia Road, Shanghai, China [*2]No.720 Xian xia Road, Shanghai, China
推荐引用方式(GB/T 7714)：
Chen Zixuan,Jia Xing,Wang Zhou,et al.TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis[J].Cellular Signalling.2024,124:111421.doi:10.1016/j.cellsig.2024.111421.
APA：
Chen Zixuan,Jia Xing,Wang Zhou,Cai Yuesong,Xu An...&Liu Min.(2024).TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis.Cellular Signalling,124,
MLA：
Chen Zixuan,et al."TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis".Cellular Signalling 124.(2024):111421

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