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F-53B stimulated vascular smooth muscle cell phenotypic switch and vascular remodeling via ferroptosis-related pathway

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机构： [1]Institute of Cardiovascular Diseases, Division of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 200336, China [2]Shanghai Institute of Pollution Control and Ecological Security, Key Laboratory of Yangtze River Water Environment Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai, China [3]Center for Translational Neurodegeneration and Regenerative Therapy, Tenth People's Hospital of Tongji University, Shanghai, China

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关键词： F-53B Vascular remodeling Vascular smooth muscle cells phenotypic switch Ferroptosis ATR LOC101929922/miR-542-3p/ACSL4

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The compound 6:2 chlorinated polyfluorinated ether sulfonate (F53B), an alternative to perfluorooctane sulfonate (PFOS), has been widely utilized in China. Although the connection between the exposure and toxicity of F53B is established, the role and mechanisms of the compound in promoting vascular remodeling are yet to be elucidated. Thus, the present study investigated the impact of F53B on the function of vascular smooth muscle cells (VSMCs) and vascular remodeling. The data exhibited that F53B stimulates vascular morphological alterations in vivo, and exposure to the compound caused excessive VSMCs ferroptosis and phenotype switching, as determined using phenotype and molecular assays. Moreover, Fer-1 reversed F-53B-induced VSMC dysfunction and vascular remodeling. Furthermore, F53B activated the ferroptosis-related pathway, encompassing ATR expression and LOC101929922/miR-542-3p/ACSL4 pathway. Thus, the current results elaborated on the multifaceted toxicities of F53B that induce vascular remodeling, thereby necessitating the assessment of vasotoxicity risks associated with the compound.Copyright © 2024. Published by Elsevier B.V.

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出版当年[2023]版：

大类 | 1 区

环境科学与生态学

小类 | 1 区环境科学

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大类 | 1 区

环境科学与生态学

小类 | 1 区环境科学

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Q1 ENVIRONMENTAL SCIENCES

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Q1 ENVIRONMENTAL SCIENCES

影响因子： 8.2 最新[2023版] 8.6 最新五年平均 9.8 出版当年[2022版] 9.6 出版当年五年平均 10.754 出版前一年[2021版] 8.2 出版后一年[2023版]

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第一作者机构： [1]Institute of Cardiovascular Diseases, Division of Cardiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 200336, China

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