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The epithelial barrier theory and its associated diseases

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收录情况： ◇ SCIE

作者：
Sun Na[1,2] * ; Ogulur Ismail[1] ; Mitamura Yasutaka[1] ; Yazici Duygu[1] ; Pat Yagiz[1] ; Bu Xiangting[1] ; Li Manru[1] ; Zhu Xueyi[1] ; Babayev Huseyn[1] ; Ardicli Sena[1,3] ; Ardicli Ozge[1,4] ; D'Avino Paolo[1] ; Kiykim Ayca[1,5] ; Sokolowska Milena[1] ; van de Veen Willem[1] ; Weidmann Lukas[6] ; Akdis Deniz[7] ; Ozdemir Banu Goker[8] ; Marie Charlotte Brüggen[9,10,11] ; Biedermann Luc[12] ; Straumann Alex[12] ; Andrea Kreienbühl[12] ; Guttman-Yassky Emma[13] ; Santos Alexandra F[14,15,16] ; Del Giacco Stefano[17] ; Traidl-Hoffmann Claudia[18] ; Jackson David J[19,20] ; Wang De-Yun[21] ; Lauerma Antti[22] ; Breiteneder Heimo[23] ; Zhang Luo[24,25] ; O'Mahony Liam[26,27] ; Pfaar Oliver[28] ; O'Hehir Robyn[29,30] ; Eiwegger Thomas[31,32,33,34] ; Fokkens Wytske J[35] ; Cabanillas Beatriz[36] ; Ozdemir Cevdet[37,38] ; Walter Kistler[39,40,41] ; Bayik Mahmut[42] ; Nadeau Kari C[43] ; Torres Maria J[44] ; Mübeccel Akdis[1] ; Jutel Marek[45] ; Agache Ioana[46] ; Akdis Cezmi A[1] ;
机构： [1]Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland [2]SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, P. R. China [3]Department of Genetics, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, Turkey [4]Division of Food Processing, Milk and Dairy Products Technology Program, Karacabey Vocational School, Bursa Uludag University, Bursa, Turkey [5]Department of Pediatrics, Division of Pediatric Allergy and Immunology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey [6]Department of Nephrology, University Hospital Zurich, Zurich, Switzerland [7]Department of Cardiology, University Hospital Zurich, Zurich, Switzerland [8]Obstetrician and Gynecologist, Nisantasi, Istanbul, Turkey [9]Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland [10]Faculty of Medicine, University of Zurich, Zurich, Switzerland [11]Department of Dermatology, University Hospital Zurich, Zurich, Switzerland [12]Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland [13]Department of Dermatology, and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA [14]Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK [15]Children's Allergy Service, Evelina London Children's Hospital, Guy's and St. Thomas' Hospital, London, UK [16]Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK [17]Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy [18]Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany [19]Guy's Severe Asthma Centre, Guy's Hospital, Guy's & St Thomas' NHS Trust, London, UK [20]School of Immunology & Microbial Sciences, King's College London, London, UK [21]Department of Otolaryngology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore City, Singapore [22]Department of Dermatology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland [23]Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria [24]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China [25]Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China [26]Department of Medicine and School of Microbiology, University College Cork, Cork, Ireland [27]APC Microbiome Ireland, Cork, Ireland [28]Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany [29]Allergy, Asthma & Clinical Immunology, The Alfred Hospital, Melbourne, Victoria, Australia [30]Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia [31]Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada [32]Department of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada [33]Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria [34]Department of Pediatric and Adolescent Medicine, University Hospital St. Pölten, St. Pölten, Austria [35]Department of Otorhinolaryngology & Head and Neck Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands [36]Department of Allergy, Instituto de Investigación Biosanitaria Hospital 12 de Octubre (imas12), Madrid, Spain [37]Department of Pediatric Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Turkey [38]Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Immunology, Istanbul University, Istanbul, Turkey [39]Department of Sports Medicine, Davos Hospital, Davos, Switzerland [40]Swiss Research Institute for Sports Medicine (SRISM), Davos, Switzerland [41]Medical Committee International Ice Hockey Federation (IIHF), Zurich, Switzerland [42]Department of Internal Medicine and Hematology, Marmara University, Istanbul, Turkey [43]Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA [44]Allergy Unit, IBIMA-Hospital Regional Universitario de Málaga-ARADyAL, UMA, Málaga, Spain [45]Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland [46]Faculty of Medicine, Department of Allergy and Clinical Immunology, Transylvania University, Brasov, Romania
出处：
DOI： 10.1111/all.16318
ISSN：

摘要：
The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial barrier theory came to light explaining the growing prevalence and exacerbations of these diseases worldwide. It attributes their onset to a functionally impaired epithelial barrier triggered by the toxicity of the exposed substances, associated with microbial dysbiosis, immune system activation, and inflammation. Diseases encompassed by the epithelial barrier theory share common features such as an increased prevalence after the 1960s or 2000s that cannot (solely) be accounted for by the emergence of improved diagnostic methods. Other common traits include epithelial barrier defects, microbial dysbiosis with loss of commensals and colonization of opportunistic pathogens, and circulating inflammatory cells and cytokines. In addition, practically unrelated diseases that fulfill these criteria have started to emerge as multimorbidities during the last decades. Here, we provide a comprehensive overview of diseases encompassed by the epithelial barrier theory and discuss evidence and similarities for their epidemiology, genetic susceptibility, epithelial barrier dysfunction, microbial dysbiosis, and tissue inflammation.© 2024 The Author(s). Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 免疫学 2 区 过敏
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 免疫学 2 区 过敏
JCR分区：
出版当年[2022]版：
Q1 ALLERGY Q1 IMMUNOLOGY
最新[2023]版：
Q1 IMMUNOLOGY Q1 ALLERGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland [2]SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, P. R. China
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Na,Ogulur Ismail,Mitamura Yasutaka,et al.The epithelial barrier theory and its associated diseases[J].Allergy.2024,79(12):3192-3237.doi:10.1111/all.16318.
APA：
Sun Na,Ogulur Ismail,Mitamura Yasutaka,Yazici Duygu,Pat Yagiz...&Akdis Cezmi A.(2024).The epithelial barrier theory and its associated diseases.Allergy,79,(12)
MLA：
Sun Na,et al."The epithelial barrier theory and its associated diseases".Allergy 79..12(2024):3192-3237

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