机构：[1]Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.[2]Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai 200336, China.[3]Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.[4]Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Songjiang, Shanghai 201620, China.
The management of critical-sized bone defects poses significant clinical challenges, particularly in the battlefield and trauma-related injuries. However, bone tissue engineering scaffolds that satisfy high porosity and good angiogenic and osteogenic functions are scarce. In this study, 3D nanofiber scaffolds decorated with strontium nanoparticles (3DS-Sr) were fabricated by combining electrospinning and gas foaming. Sodium borohydride (NaBH4) served a dual role as both a reducing and gas-foaming agent, enabling a one-step process for expansion and modification. In vitro experimental results demonstrated that 3DS-Sr possessed an integrated multilayered porous structure. It promoted angiogenesis by upregulating the expression of hypoxia-inducible factor-1α (HIF-1α) protein and phosphorylation of ERK through the sustained release of Sr2+ and created a favorable microenvironment for osteogenesis by activating the Wnt/β-catenin pathway. In vivo experiments indicated that 3DS-Sr promoted cranial bone regeneration by synergistically promoting the effects of vascularization and osteogenesis. In summary, this study proposed a bioactive bone scaffold in a "one stone, two birds" manner, providing a promising strategy for bone defect repair.
基金：
This research was supported by the Science and Technology
Commission of Shanghai Municipality (22Y11912000),
Medical and Industrial Cross Research Foundation of “Star
of Jiaotong University” Program of Shanghai Jiao Tong
University, China (Grant No. YG2022ZD030), Laboratory
Open Fund of Key Technology and Materials in Minimally
Invasive Spine Surgery (2024JZWC-YBA01), Tongren Hospital
Introduces the Talented Person Scientific Research Start
Funds Subsidization Project (TR2023rc08).
第一作者机构：[1]Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.[2]Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai 200336, China.[3]Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
共同第一作者：
通讯作者：
通讯机构：[1]Laboratory of Key Technology and Materials in Minimally Invasive Spine Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.[2]Center for Spinal Minimally Invasive Research, Shanghai Jiao Tong University, Shanghai 200336, China.[3]Department of Orthopaedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
推荐引用方式(GB/T 7714)：
Chen Yujie,Li Yucai,Wang Xinyi,et al.One-Step Gas Foaming Strategy for Constructing Strontium Nanoparticle Decorated 3D Scaffolds: a New Platform for Repairing Critical Bone Defects[J].ACS Applied Materials & Interfaces.2024,16(45):61664-61678.doi:10.1021/acsami.4c13119.
APA：
Chen Yujie,Li Yucai,Wang Xinyi,Mo Xiumei,Chen Yicheng...&Yu Jiangming.(2024).One-Step Gas Foaming Strategy for Constructing Strontium Nanoparticle Decorated 3D Scaffolds: a New Platform for Repairing Critical Bone Defects.ACS Applied Materials & Interfaces,16,(45)
MLA：
Chen Yujie,et al."One-Step Gas Foaming Strategy for Constructing Strontium Nanoparticle Decorated 3D Scaffolds: a New Platform for Repairing Critical Bone Defects".ACS Applied Materials & Interfaces 16..45(2024):61664-61678
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