To the Editor, Despite the deleterious effects of particulate matter (PM) exposure on asthma, the underlying mechanism remains unclear currently.1 DNA methylation of peripheral blood mononuclear cells (PBMCs) is a potential mechanism that bridges the gap between exogenous exposure and genome, which rapidly influences incidence and progression of diseases.2 In this study, human PBMCs (hPBMCs) isolated from individuals pre- and post-PM exposure were subjected to the methylated DNA immunoprecipitation sequencing. Among 1, 443 differentially methylated genes following PM exposure, we identified 49 overlapping genes related to PM-induced diseases based on the comparative toxicogenomics database (CTD, https://ctdbase. org/) 3 (Figure 1A). KEGG pathway analysis upon overlapping genes presented enrichment of the retinoic acid receptor-related orphan receptor C (RORC) in the T helper 17 (Th17) cell differentiation pathway (Figure 1B).
基金：
National Key R&D Program of China (2022YFC2504100 and 2022YFC2504101, 2023YFC3708300 and 2023YFC3708303); the National Science Fund for Distinguished Young Scholars (82025031); the Beijing Outstanding Young Scientist
Program (JWZQ20240101024); the Youth Beijing Scholar Program; the
Chinese Institutes for Medical Research (CX23YZ01), Beijing; High level talent in Public Health of Beijing (Discipline leaders-03-29).
第一作者机构：[1]Capital Med Univ, Sch Publ Hlth, Xitoutiao 10, Beijing 100069, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Sch Publ Hlth, Xitoutiao 10, Beijing 100069, Peoples R China[2]Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing 100005, Peoples R China[3]Beijing Municipal Educ Commiss, Beijing Lab Allerg Dis, Beijing, Peoples R China[4]Capital Med Univ, Lab Environm Hlth & Allerg Nasal Dis, Lab Clin Med, Beijing, Peoples R China[5]Fourth Mil Med Univ, Minist Educ, Key Lab Hazard Assessment & Control Special Operat, Dept Occupat & Environm Hlth, Xian, Peoples R China
推荐引用方式(GB/T 7714)：
Li Bin,Zhang Yuan,Huang Nannan,et al.DNA hypomethylation of Th17 cells by ambient particulate pollutants enhances neutrophil recruitment in murine models of allergic airway inflammation[J].ALLERGY.2024,doi:10.1111/all.16389.
APA：
Li, Bin,Zhang, Yuan,Huang, Nannan,Wang, Jing,Zhang, Xianan...&Zhang, Luo.(2024).DNA hypomethylation of Th17 cells by ambient particulate pollutants enhances neutrophil recruitment in murine models of allergic airway inflammation.ALLERGY,,
MLA：
Li, Bin,et al."DNA hypomethylation of Th17 cells by ambient particulate pollutants enhances neutrophil recruitment in murine models of allergic airway inflammation".ALLERGY .(2024)
医学