Having good antibacterial properties and promoting soft and hard tissue repair are the keys to successful implantation of intraosseous transcutaneous. Polyether ether ketone (PEEK) is a class of FDA-approved polymer implants. However, the surface of PEEK is bioinert, which is easy to cause postoperative infection and poor tissue integration. In this study, polypyrrole (Ppy) was polymerized on sulfonated PEEK, Mg-3(PO4)(2) nanosheets were grown in situ on one side, and polycaprolactone (PCL) was then spun on the surface to form a Janus-like surface on PEEK. The Ppy/Mg-3(PO4)(2)/PCL composite coating could inhibit bacterial adhesion, and the excellent photothermal properties of Ppy/Mg-3(PO4)(2)/PCL and Ppy coatings further promote the removal of bacteria due to the accumulated heat. After the infection was eliminated, the Janus-like surface of modified PEEK switched macrophages to anti-proinflammatory response and promoted both soft and hard tissue repair. The Ppy modified sulfonated PEEK could promote collagen secretion in the soft tissue, while the PCL films on Ppy/Mg-3(PO4)(2)/PCL was densified by temperature response under near-infrared light treatment to close the exposed interface of Mg-3(PO4)(2) nanosheets that was more conducive to bone repair. In summary, PEEK with Janus-like surface consisting of Ppy/Mg-3(PO4)(2)/PCL and Ppy has multiple biological functions of sequential antibacterial and soft and hard tissue repair, and is a promising candidate material for intraosseous transcutaneous implants.
基金:
National Natural Science Foundation of China [U21A20100, 82472461, 32371397]; Fundamental Research Funds for The Central Universities [YG2023ZD29]; Pioneer" and "Leading Goose" R & D Program of Zhejiang [2024C03080]; Laboratory Open Fund of Key Technology and Materials in Minimally Invasive Spine Surgery [2024JZWC-YBA04, 2024JZWC-ZDB03]; Talent project of Shanghai Tongren Hospital [TRKYRC-xx02]; Research Fund of Shanghai Tongren Hospital; Shanghai Jiaotong University School of Medicine [2023DHYGJC-YBA01]
第一作者机构:[1]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine M, Shanghai 200050, Peoples R China[2]Shanghai Jiao Tong Univ, Tongren Hosp, Lab Key Technol & Mat Minimally Invas Spine Surg, Sch Med, Shanghai 200050, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine M, Shanghai 200050, Peoples R China[4]Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, 1 Sublane Xiangshan, Hangzhou, Peoples R China
推荐引用方式(GB/T 7714):
Liu Xingdan,Zhang Haifeng,Tan Ji,et al."Janus" PEEK implant with sandwich Mg-containing coating for infected tissue repair[J].COMPOSITES PART B-ENGINEERING.2025,289:doi:10.1016/j.compositesb.2024.111938.
APA:
Liu, Xingdan,Zhang, Haifeng,Tan, Ji,Lu, Ziyi,Peng, Xiaochun...&Liu, Xuanyong.(2025)."Janus" PEEK implant with sandwich Mg-containing coating for infected tissue repair.COMPOSITES PART B-ENGINEERING,289,
MLA:
Liu, Xingdan,et al.""Janus" PEEK implant with sandwich Mg-containing coating for infected tissue repair".COMPOSITES PART B-ENGINEERING 289.(2025)