机构：[1]Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China [2]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Autoimmune uveitis and posterior scleritis are ocular diseases caused by immune dysregulation. Their pathogenesis remains elusive, and delayed diagnosis can exacerbate vision loss. Our study analyzed proteomic profiles of 190 patients with Behcet's disease uveitis, posterior scleritis, and Vogt-Koyanagi-Harada syndrome. Bioinformatics methods revealed potential pathogenesis and biomarkers for the diseases, which were verified by enzyme-linked immunosorbent assay. The diagnostic accuracy was improved by constructing a biomarker combination. In addition, we used the Connectivity Map tool to analyze the differentially expressed proteins and identified small molecules with potential clinical applications. In this study, EMINIL1 and LYZ were identified as biomarkers for Behcet's uveitis, GSTP1 and PGLYRP1 for posterior scleritis, and APOH and STXBP1 for Vogt-Koyanagi-Harada syndrome. This study mapped the plasma proteins of these diseases, revealing potential pathogenesis and clinical applications of these biomarkers.
基金：
National Natural Science Foundation of China, China [82371044, 82171042]; Tianjin Key Medical Discipline (Specialty) Project, China [TJWJ2023XK009]; Tianjin Binhai New Area Health Research Project, China [2023BWKQ018]
第一作者机构：[1]Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Xueru,An Jinying,Wu Lingzi,et al.Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis[J].ISCIENCE.2024,27(12):doi:10.1016/j.isci.2024.111389.
APA：
Li, Xueru,An, Jinying,Wu, Lingzi,Tao, Qingqin,Zhang, Hui&Zhang, Xiaomin.(2024).Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis.ISCIENCE,27,(12)
MLA：
Li, Xueru,et al."Developing the biomarker panels and drugs by proteomic analysis for autoimmune uveitis and posterior scleritis".ISCIENCE 27..12(2024)
