机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.医技科室麻醉科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.[3]Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700, China.
To the Editor: Posttraumatic stress disorder (PTSD), a severe psychiatric disorder post-trauma, is closely linked to fear memory.[1] Current treatments like selective serotonin reuptake inhibitors have limited effectiveness and side effects, necessitating new non-invasive approaches. PTSD often co-occurs with depression, and both are connected to inflammatory system disruptions, with increased proinflammatory cytokines in patients.[2,3] Transcutaneous auricular vagus nerve stimulation (taVNS) shows promise for treating depression by reducing neuroinflammation.[4] taVNS combines traditional Chinese medicine auricular acupuncture and neuroanatomy, targeting the auricular branch of the vagus nerve to influence brain regions like the thalamus and hippocampus. This study hypothesizes that taVNS may reduce fear memory among fear-conditioned mice through the modulation of inflammatory responses. We utilized a fear-conditioning mouse model to evaluate the impact on freezing behavior and quantify inflammatory markers, including corticosterone, interleukin-10 (IL-10) and interleukin-1β (IL-1β), within both serum and brain regions.
基金：
the priming scientific research foundation for the junior researcher
in Beijing Tongren Hospital, Capital Medical University
(No. 2023-YJJ-ZZL-018), the National Natural Science
Foundation of China (No. 82270411), the Beijing Hospitals Authority’s Ascent Plan (No. DFL20220203), and the
Capital’s Funds for Health Improvement and Research (No.
CFH2024-2-2058).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区医学
小类|3 区医学：内科
最新[2023]版：
大类|3 区医学
小类|3 区医学：内科
第一作者：
第一作者机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Du Yingjie,Zhang Yue,Bai Yafan,et al.Transcutaneous auricular vagus nerve stimulation might reduce fear memory in fear-conditioned mice through an anti-neuroinflammatory mechanism[J].Chinese Medical Journal.2024,doi:10.1097/CM9.0000000000003404.
APA：
Du Yingjie,Zhang Yue,Bai Yafan,Liu Min,Zhang Congya...&Wang Guyan.(2024).Transcutaneous auricular vagus nerve stimulation might reduce fear memory in fear-conditioned mice through an anti-neuroinflammatory mechanism.Chinese Medical Journal,,
MLA：
Du Yingjie,et al."Transcutaneous auricular vagus nerve stimulation might reduce fear memory in fear-conditioned mice through an anti-neuroinflammatory mechanism".Chinese Medical Journal .(2024)
