Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai
机构：[1]Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.[2]Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.[3]Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.[4]Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.[5]Department of Hematology, Tongji Hospital of Tongji University, Shanghai 200065, China.[6]Department of Hematology, Xuhui Hospital, Fudan University, Shanghai 200031, China.[7]Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.[8]Department of Hematology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.[9]Department of Hematology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.[10]Department of Hematology, Myeloma & Lymphoma Center, Shanghai Changzheng Hospital, 200003 Shanghai, China.[11]Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China.[12]Department of Hematology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China.[13]Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, Shanghai Fengxian District Central Hospital, Shanghai 201499, China.[14]Department of Hematology, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai 201700, China.[15]Department of Hematology and Oncology, Minhang Hospital, Fudan University, Shanghai 201199, China
In this real-world study, 153 adult T-cell lymphoblastic lymphoma (T-LBL) patients from sixteen centers in Shanghai were enrolled. Out of them, 103 (67.3%) achieved complete remission (CR). The 2-year overall survival (OS) and progression-free survival (PFS) were 56.3% and 47.6%, respectively. In multivariate analysis, CR after induction treatment significantly improved the OS (p = 0.002) and PFS (p = 0.001). Among CR patients, allogeneic peripheral blood stem cell transplantation (allo-PBSCT) significantly lowered the cumulative incidence of relapse (CIR) compared to autologous PBSCT (p = 0.043) and non-SCT (p = 0.001). Among patients undergoing allo-PBSCT in CR, early (within four induction courses) and late CR (after four induction courses) didn't impact the prognosis with similar 2-year OS (p = 0.590), PFS (p = 0.858), CIR (p = 0.50), and non-relapse mortality (NRM) (p = 0.110). Early and deferred allo-PBSCT for early CR patients also yielded similar 2-year OS (p = 0.640), PFS (p = 0.970), CIR (p = 0.994), and NRM (p = 0.974). As a time-dependent covariate, allo-PBSCT presented a positive effect on PFS (p = 0.018) and had a trend toward better OS (p = 0.064). These data suggested that allo-PBSCT should be considered for T-LBL patients upon achieving CR to enhance survival and reduce relapse risk.
基金：
National Natural Science Foundation of China (National Science Foundation of China) [2019YFA0111000]; National Key R&D Program of China [SHDC2020CR1012B]; Shanghai Shen Kang Hospital Development Center [81570148]; National Natural Science Foundation of China [CCTR-2022C04]; Clinical Research Innovation Plan of Shanghai General Hospital
第一作者机构：[1]Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China.
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推荐引用方式(GB/T 7714)：
Yu Fangfang,Niu Jiahua,Yang Jianmin,et al.Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai[J].BONE MARROW TRANSPLANTATION.2024,doi:10.1038/s41409-024-02500-2.
APA：
Yu, Fangfang,Niu, Jiahua,Yang, Jianmin,Hou, Jian,Hao, Siguo...&Song, Xianmin.(2024).Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai.BONE MARROW TRANSPLANTATION,,
MLA：
Yu, Fangfang,et al."Optimal timing and impact of allogeneic peripheral blood stem cell transplantation in adult T-cell lymphoblastic lymphoma: insights from a large cohort multi-center real-world study in Shanghai".BONE MARROW TRANSPLANTATION .(2024)
