机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China,临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China,临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China,研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China
Background Several epidemiological studies have shown that allergic rhinitis (AR) patients are more susceptible to coronavirus disease 2019 (COVID-19).Objective We aim to investigate the risk factors for COVID-19 in AR patients.Methods A retrospective nationwide cohort study was conducted based on a questionnaire survey in China. The baseline characteristics, region of residence, smoking and drinking status, comorbidities, vaccination status and previous infection information were obtained. Allergen test results, the SARS-CoV-2 nucleic acid test, and antigen detection results were collected. Information on AR and comorbid medication use pre-SARS-CoV-2 infection was also collected. Binary logistic regression and analysis of covariance (different adjusted models) were conducted.Results In all, 830 AR patients were included; 627 patients (75.54%) were infected with SARS-CoV-2. AR comorbid with allergic conjunctivitis (AC) was a protective factor [OR: 0.525 (95% CI = 0.296-0.929), P = 0.027] against SARS-CoV-2 infection, while AR comorbid with food allergy was a risk factor [OR: 6.404 (95% CI = 1.349-30.402), P = 0.0195]. Although fewer patients received four doses of the vaccine, the results showed a significant protective effect against SARS-CoV-2 infection in AR patients [OR: 0.093 (95% CI = 0.025-0.348), P = 0.0004]. Underweight was a protective factor against COVID-19 [OR: 0.287 (95% CI = 0.147-0.562), P = 0.0003] after full multivariable adjustment. Overweight was associated with a 2.071-fold higher risk for COVID-19 compared with normal weight [(95% CI = 1.045-4.105), P = 0.0370]. Additionally, house dust mite (HDM)-specific allergies were also protective against COVID-19 [OR: 0.537 (95% CI = 0.290-0.996), P = 0.0484].Conclusions This study revealed underlying protective and risk factors, which might be used to improve the management of AR and COVID-19.
基金：
National Key R&D Program of China (2022YFC2504100), the program for the Changjiang Scholars
and Innovative Research Team (IRT13082), the National Natural
Science Foundation of China (82171110), the CAMS Innovation
Fund for Medical Sciences (2019-I2M-5-022), Special Funds for
the Construction of High-level Public Health Technical Talents
(Lingjunrencai-01-08, Lingjunrencai-02-09), Beijing Municipal
Science & Technology Commission (Z211100002921057), the
Capital’s Funds for Health Improvement and Research (CFH
2022-1-1091, CFH 2024-4-1093), the Beijing Natural Science
Foundation (7222024), the Beijing New-star Plan of Science and
Technology (20220484226), Beijing Municipal Public Welfare
Development and Reform Pilot Project for Medical Research
Institutes (JYY2021-2), Beijing Hospitals Authority Innovation
Studio of Young Staff Funding Support (202306).
第一作者机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China,[2]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China,[3]Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China,[2]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China,[3]Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China,[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Yang Xiaozhe,Sima Yutong,Zhao Jinming,et al.Risk and protective factors for coronavirus disease 2019 (COVID-19) in allergic rhinitis patients: a national survey in China[J].FRONTIERS IN ALLERGY.2024,5:doi:10.3389/falgy.2024.1479493.
APA：
Yang, Xiaozhe,Sima, Yutong,Zhao, Jinming,Zhang, Jing,Wang, Xiangdong&Zhang, Luo.(2024).Risk and protective factors for coronavirus disease 2019 (COVID-19) in allergic rhinitis patients: a national survey in China.FRONTIERS IN ALLERGY,5,
MLA：
Yang, Xiaozhe,et al."Risk and protective factors for coronavirus disease 2019 (COVID-19) in allergic rhinitis patients: a national survey in China".FRONTIERS IN ALLERGY 5.(2024)
