高级检索
当前位置: 首页 > 详情页

Comparison of retinal vascular abnormalities in the fellow eyes of children with Coats' disease and normal subjects using ultra-widefield fundus fluorescein angiography

文献详情

资源类型:
WOS体系:
Pubmed体系:

收录情况: ◇ SCIE

机构: [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China
出处:
ISSN:

关键词: Coats’ disease Ultra-widefield fluorescein angiography Peripheral vascular abnormalities Children Fellow eye

摘要:
To investigate retinal vascular abnormalities in the affected and fellow eyes of children with Coats' disease using Optos® ultra-widefield fundus fluorescein angiography (UWFFA) and compare the peripheral vascular abnormalities between fellow eyes and normal control eyes.Children diagnosed with Coats' disease who underwent UWFFA were retrospectively reviewed. Healthy eyes with complete UWFFA data were selected as controls. Retinal vascular abnormalities of the primary affected, fellow eyes and normal control eyes were recorded by investigating the UWFFA images.Among the 190 eyes of 95 patients with unilateral Coats' disease, 83 (87.4%) were male, and the median age was 9.00 (7.00, 12.25) years (4-18 years). 93 (97.9%) fellow eyes had peripheral capillary telangiectasia that most commonly located in the temporal periphery. 59 (62.1%) fellow eyes had microaneurysms and 19 (20.0%) had vascular leakage; 29 (30.5%) fellow eyes had peripheral vascular tortuosity and 86 (90.5%) eyes had peripheral right-angle vessels. Peripheral capillary non-perfusion (CNP) were found in 31.6% (30/95) fellow eyes. We also found that the terminal vascular patterns in the fellow eyes were mainly loop pattern, accounting for 90.5%. The incidence of capillary bed abnormalities, vascular leakage, right-angle vessels and CNP were significantly higher in fellow eyes of Coats' disease than control eyes (p<0.001, p=0.044, p<0.001, p=0.001, respectively). Regarding the terminal vascular patterns, the proportion of loop pattern in fellow eye group was significantly higher than that in control eye group (p<0.001). A total of 21 Coats' patients had follow-up UWFFA data. The average follow-up time was 13.19±10.09 (3-35) months. There was no significant change in peripheral retinal vascular abnormalities in the fellow eye of all patients between the first and last visit.Because Optos® UWFFA device is able to quickly take panoramic fundus images using mild excitation light without contacting the cornea, it allows the detection of peripheral vascular changes in the fellow eyes of children with Coats' disease. Contrary to the previous belief that Coats' disease is a "unilateral condition", our finding shows that Coats' disease appears to be a highly asymmetric bilateral disease, and the peripheral vascular abnormalities in the fellow eye remains stable in short term.Copyright © 2024. Published by Elsevier B.V.

基金:
语种:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2025]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学
最新[2025]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学
JCR分区:
出版当年[2023]版:
Q2 ONCOLOGY
最新[2024]版:
Q3 ONCOLOGY

影响因子: 最新[2024版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版] 出版后一年[2024版]

第一作者:
第一作者机构: [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China
通讯作者:
通讯机构: [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:25910 今日访问量:0 总访问量:1514 更新日期:2025-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持:重庆聚合科技有限公司 地址:北京市东城区东交民巷1号(100730)