机构：[1]Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[2]Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University, Gubei Branch, Shanghai, China.[3]Department of Otorhinolaryngology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[4]Department of Respiratory and Critical Care Medicine, Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China.[5]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
To the editor, Allergic diseases are a worldwide public health problem, which exhibit a series of severity and vary prevalence among several types [1]. Alterations of metabolites have been detected in allergic disease patients [2, 3], whereas few studies focus on the association between serum metabolites and allergic diseases [4]. Here, we harnessed the genome-wide association studies database (GWAS) and systematically assessed the links between serum metabolites and common allergic diseases by using twosample Mendelian randomization (MR) analysis to explore whether serum metabolites play a role in the pathophysiologic changes and thus give new insights to the treatment and prevention of allergic diseases.
基金：
Anesthesiology and Critical Care Medicine Master and Doctor Innovation Talent Base Foundation of Changning
District (No. RCJD2021S02), the Key Discipline of Tongren Hospital (No. tr2023xk09), the Aging Anesthesia Innovation Team (No. 2021RC02), and Key
Discipline of Shanghai Municipal Commission of Health (No. 2024ZDXK0055).
第一作者机构：[1]Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[5]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
推荐引用方式(GB/T 7714)：
Qiu Yanli,Zhang Bing,Chen Haocong,et al.The Causal Relationship Between Serum Metabolites and Allergic Diseases: Mendelian Randomization Analysis[J].Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology.2025,55(5):436-439.doi:10.1111/cea.14615.
APA：
Qiu Yanli,Zhang Bing,Chen Haocong,Zhang Jialin,Zhang Yu...&Lu Yinzhong.(2025).The Causal Relationship Between Serum Metabolites and Allergic Diseases: Mendelian Randomization Analysis.Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology,55,(5)
MLA：
Qiu Yanli,et al."The Causal Relationship Between Serum Metabolites and Allergic Diseases: Mendelian Randomization Analysis".Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology 55..5(2025):436-439
