机构：[1]Rothschild Foundation Hospital, Institut Francais de Myopie, Paris, France[2]Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore[3]Private Practice, Professor Jonas and Dr. Panda-Jonas, Heidelberg, Germany[4]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China[5]L. V. Prasad Eye Institute, L. V. Prasad Marg, Banjara Hills, Hyderabad, Telangana, India[6]Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany[7]Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore, Singapore[8]Corneal and External Eye Disease Service, Singapore National Eye Centre, Singapore, Singapore[9]Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany
The purpose of this study was to examine anatomic relationships between Descemet's membrane (DM) and neighboring tissues.Human eyes enucleated due to malignant uveal melanoma were histomorphometrically examined.In all 50 eyes included in the study (age = 59.2 ± 13.3 years), a cellular tissue (mean thickness at the DM end = 14.2 ± 19.5 µm), originating in the transitional zone, extended into the space between the peripheral DM and corneal stroma for a length of 142 ± 71 µm. This length decreased with the longer part of the DM covered with Hassall-Henle-bodies (beta = -0.30, B = -0.28, 95% confidence interval [CI] = -0.54 to -0.03, P = 0.03) and was not related with age (P = 0.84), axial length (P = 0.94), transitional zone length (P = 0.51), and the DM-scleral spur distance (P = 0.72). The DM thinned toward its end and the DM-like components appeared getting together and merging with transitional zone tissue fibers. The transitional zone length (mean = 267 ± 115 µm) varied from 82 µm to 586 µm, increased with longer DM-scleral spur distance (beta = 0.80, B = 0.67, 95% CI = 0.52 to 0.82, P < 0.001), and was not related with axial length (P = 0.74) or age (P = 0.18). The DM-scleral spur distance (mean = 660 ± 136 µm, range = 302 µm-979 µm) was not related with axial length (P = 0.60) or age (P = 0.06). The scleral spur dimensions (basis = 193 ± 103 µm, height = 151 ± 46 µm, length = 231 ± 75 µm) were not related with the DM-scleral spur distance (all P > 0.35), axial length (all P > 0.07), and age (all P > 0.25). In all eyes, the scleral spur tip was orientated anteriorly, with the longitudinal ciliary muscle inserting at its posterior side.DM is firmly connected with the transitional zone tissue, and indirectly through the corneoscleral TM, with the scleral spur. With the latter connected through the longitudinal ciliary muscle and Bruch's membrane with the optic disc, the DM is part of an anatomic spherical unit of the globe.
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外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|2 区医学
小类|2 区眼科学
最新[2025]版：
大类|2 区医学
小类|2 区眼科学
第一作者：
第一作者机构：[1]Rothschild Foundation Hospital, Institut Francais de Myopie, Paris, France[2]Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore[3]Private Practice, Professor Jonas and Dr. Panda-Jonas, Heidelberg, Germany[4]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China[5]L. V. Prasad Eye Institute, L. V. Prasad Marg, Banjara Hills, Hyderabad, Telangana, India
共同第一作者：
通讯作者：
通讯机构：[1]Rothschild Foundation Hospital, Institut Francais de Myopie, Paris, France[2]Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore[3]Private Practice, Professor Jonas and Dr. Panda-Jonas, Heidelberg, Germany[4]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China[5]L. V. Prasad Eye Institute, L. V. Prasad Marg, Banjara Hills, Hyderabad, Telangana, India
推荐引用方式(GB/T 7714)：
Jonas Jost B,Panda-Jonas Songhomitra,Mehta Jodhbir S,et al.Anatomic Relationship Among Descemet's Membrane, Trabecular Meshwork, Scleral Spur, and Ciliary Muscle[J].Investigative Ophthalmology & Visual Science.2025,66(2):8.doi:10.1167/iovs.66.2.8.
APA：
Jonas Jost B,Panda-Jonas Songhomitra,Mehta Jodhbir S&Jonas Rahul A.(2025).Anatomic Relationship Among Descemet's Membrane, Trabecular Meshwork, Scleral Spur, and Ciliary Muscle.Investigative Ophthalmology & Visual Science,66,(2)
MLA：
Jonas Jost B,et al."Anatomic Relationship Among Descemet's Membrane, Trabecular Meshwork, Scleral Spur, and Ciliary Muscle".Investigative Ophthalmology & Visual Science 66..2(2025):8
