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The effects of long-term low-dose aspirin on coagulation function in gynaecological patients with co-existing chronic periodontitis

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机构： [1]Fudan Univ, Eye & ENT Hosp, Dept Stomatol, Shanghai, Peoples R China [2]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Oral & maxillofacial Surg,Luwan Branch, Shanghai 200020, Peoples R China [3]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Stomatol, Shanghai, Peoples R China [4]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Oral & maxillofacial Surg, Shanghai 200020, Peoples R China [5]Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Oncol, Wuxi Branch,Med Coll, Wuxi 214021, Jiangsu, Peoples R China [6]Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gen Surg,Luwan Branch, Shanghai 200020, Peoples R China

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关键词： Intrauterine adhesions polycystic ovary syndrome aspirin periodontitis bleeding risk

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This study investigates the safety of non-surgical periodontal treatment during long-term low-dose aspirin therapy in patients with chronic periodontitis and gynaecological conditions, focusing on bleeding risk and coagulation function. Patients received low-dose aspirin (100 mg/d) and were divided into a medication continuation group (observation) and a cessation group (control), with 41 patients each. Key periodontal parameters (plaque index, probing depth, attachment loss) and coagulation indices (activated partial thromboplastin time, prothrombin time, thrombin time, prothrombin activity) were assessed post-treatment. Results showed no significant difference in coagulation indices and bleeding scores between the groups (P > 0.05). Grade 3 bleeding incidents were slightly higher in the observation group but not statistically significant. The observation group's maximum platelet aggregation rate was significantly lower (P < 0.0001), with no significant differences in activated partial thromboplastin time, prothrombin time, thrombin time, or prothrombin activity. The findings suggest that non-surgical periodontal treatment is safe for these patients under long-term low-dose aspirin therapy, with limited increased bleeding risk. (AfrJReprod Health 2025; 29 [1]: 153-159).

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出版当年[2025]版：

大类 | 4 区医学

小类 | 4 区公共卫生、环境卫生与职业卫生

最新[2025]版：

大类 | 4 区医学

小类 | 4 区公共卫生、环境卫生与职业卫生

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出版当年[2023]版：

Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

最新[2023]版：

Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

影响因子： 0.7 最新[2023版] 1 最新五年平均 0.7 出版当年[2023版] 1 出版当年五年平均 1 出版前一年[2022版]

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第一作者机构： [1]Fudan Univ, Eye & ENT Hosp, Dept Stomatol, Shanghai, Peoples R China

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