Cataracts represent one of the leading causes of blindness globally. The World Health Organization's 2019World Report on Vision indicates that approximately 65.2 million individuals worldwide experience varying degrees of visual impairment or blindness attributable to cataracts. The prevalence of this condition is significantly increasing, largely due to the accelerated aging of the global population. The lens of the eye is primarily composed of crystallins, which are categorized into three families: α-, β-, and γ-crystallins. The highly ordered structure and interactions among these crystallins are crucial for maintaining lens transparency. Disruptions in the interactions within or between crystallins can compromise this delicate architecture, exposing hydrophobic surfaces that lead to crystallin aggregation and subsequent cataract formation. Currently, surgical intervention is the sole treatment for cataracts, and the cataract surgery rate in China remains considerably lower than that of developed nations. Investigating the mechanisms of crystallins interaction and aggregation is essential for understanding the molecular pathogenesis of cataract formation, which may inform the development of targeted therapies and preventative strategies. This paper reviews recent scientific advancements in the research field of lens crystallins aggregation and cataract formation.Copyright © 2025. Published by Elsevier Ltd.