Purpose/Objectives: The wound healing process can be divided into four distinct stages, including coagulation, inflammation, proliferation, and remodeling. On the one hand, eradication of bacterial infections and excess reactive oxygen species (ROS) during the clotting and inflammation phases is critical, as ongoing inflammation and oxidative stress can greatly affect the wound healing process. Metal-phenolic networks (MPNs) has attracted extensive attention in antimicrobial therapy due to its excellent anti-inflammatory, antioxidation, antibacterial and good biocompatibility properties. On the other hand, in the phase of proliferation and remodeling, promoting the polarization of M1 macrophages to M2 macrophages and angiogenesis are the keys to accelerate tissue regeneration. Astragaloside IV is widely used in the field of wound healing and can promote angiogenesis by activating small ubiquitin-related modifiers of HIF1a. Simultaneously, 3D printing technology is also developing rapidly in the field of biomaterials, which holds great promise for wound healing due to its highly adjustable and breathable loose structure. Therefore, it is possible to combine 3D printing technology with a bio-ink with antibacterial, anti-inflammatory, antioxidative, pro-angiogenic, and immune-regulating properties to construct a 3D-bioprinted multifunctional hydrogel patch with wide application prospects in promoting wound healing.