Association of HIV infection, other sexually transmitted infections or their coexistence with mpox among men who have sex with men: A national questionnaire-based study in China using propensity score matching
Background: A marked increase in mpox cases was observed in May 2022 in previously non-endemic regions. The men who have sex with men (MSM) population exhibited a disproportionately higher rate of infection. Objectives: This study aimed to investigate the coexistence of HIV infection and other sexually transmitted infections (STIs) and their association with mpox among MSM, with validatiton conducted through a casecontrol study utilizing propensity score matching (PSM). Methods: A total of 2403 eligible MSM participants were recruited for a cross-sectional study conducted across six geographically representative regions of China from October 2023 to March 2024. Data were collected via an anonymous online questionnaire. Univariable and multivariable logistic regression analyses were performed to evaluate the association between status of HIV infection and other STIs and risk of mpox. Validatiton was conducted through a case-control study employing PSM. Results: Among the total 2403 participants, 56 (2.33 %) reported diagnosis of mpox. Taking participants negative for both HIV infection and other STIs (group 1) as reference, the adjusted ORs (95 % CIs) (p value) for mpox were 2.00 (0.60-6.65) (p = 0.256), 6.26 (2.97-13.16) (p < 0.001), and 8.72 (3.45-22.00) (p < 0.001) for those who were only positive for HIV infection (group 2), only positive for other STIs (group 3) and positive for both (group 4), respectively. In the case-control study, 53 participants from the mpox group were matched to 149 participants from the non-infection group at a ratio of 1:3. The positive association between status of HIV infection and other STIs and mpox persisted, with adjusted ORs (95 % CIs) (p value) of 1.53 (0.38-6.11) (p = 0.547), 7.01 (3.00-16.38) (p < 0.001), and 6.20 (2.21-17.43) (p < 0.001) for group 2 to group 4, respectively. Conclusions: This study demonstrated a significant association between other STIs and the risk of mpox among MSM. HIV infection alone didn't significantly increase the risk of mpox, while other STIs were found to be strong and robust risk factors for mpox. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
基金：
Key discipline projects of Shanghai Three-Year Action Plan for Public Health [GWVI-11.1-29]; Public Health Research Project from Shanghai Disease Control and Prevention Administration [2024GKM30]; National Health Commission of the PRC [Z155080000004]; Science and Technology Commission Shanghai Municipality [20JC1410204]; Tongren Hospital Talent Launch Project [TR2023rc11, TR2024RC10]; Changning District Medical and Health Research Special Project [CNKW2022Y08]; Research Fund of Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine [TRYJ2024LC13, TRYJ2022LC10]
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区医学
小类|3 区传染病学3 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|3 区医学
小类|3 区传染病学3 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2023]版：
Q1INFECTIOUS DISEASESQ1PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q1INFECTIOUS DISEASESQ1PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Publ Hlth Res Ctr, Sch Med, 1111 XianXia Rd, Shanghai 200336, Peoples R China[2]Shanghai Jiao Tong Univ, Sch Publ Hlth, 227 South Chongqing Rd, Shanghai 200025, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Publ Hlth Res Ctr, Sch Med, 1111 XianXia Rd, Shanghai 200336, Peoples R China[5]Shanghai Jiao Tong Univ, China Hosp Dev Inst, Ctr Community Hlth Care, 227 South Chongqing Rd, Shanghai 200025, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Meihui,Wang Yuxuan,Zhang Yinghuan,et al.Association of HIV infection, other sexually transmitted infections or their coexistence with mpox among men who have sex with men: A national questionnaire-based study in China using propensity score matching[J].JOURNAL OF INFECTION AND PUBLIC HEALTH.2025,18(6):doi:10.1016/j.jiph.2025.102737.
APA：
Zhang, Meihui,Wang, Yuxuan,Zhang, Yinghuan,Wang, Ying,Chen, Jianyu...&Cai, Yong.(2025).Association of HIV infection, other sexually transmitted infections or their coexistence with mpox among men who have sex with men: A national questionnaire-based study in China using propensity score matching.JOURNAL OF INFECTION AND PUBLIC HEALTH,18,(6)
MLA：
Zhang, Meihui,et al."Association of HIV infection, other sexually transmitted infections or their coexistence with mpox among men who have sex with men: A national questionnaire-based study in China using propensity score matching".JOURNAL OF INFECTION AND PUBLIC HEALTH 18..6(2025)
