Engineering cuttlefish melanin nanoparticles: A dual-action therapy for acute radiation syndrome and combined radiation-wound injuries via regulating Bcl-2 family proteins and caspases in the apoptotic process
Ionizing radiation (IR) injuries are featured as acute radiation syndrome (ARS) and localized combined radiation-wound injury (CRWI). While scavenging reactive oxygen species (ROS) is a key strategy for mitigating IRinduced damage, the development of effective marine natural biomaterials for treatment remains rare and challenging. In this study, we engineered cuttlefish melanin nanoparticles (CMNs) and incorporated them into a poly (vinyl alcohol) (PVA) and sodium alginate (SA) matrix, enabling the in situ synthesis of PVA/SA@CMNs (PS@CMNs) hydrogels with multifaceted therapeutic benefits. CMNs pretreatment significantly alleviated radiation-induced damage in ARS models, particularly by protecting the hematopoietic and immune systems. Furthermore, PS@CMNs hydrogels exhibited exceptional antioxidant, photothermal antibacterial, and biodegradable properties than CMNs. Upon near-infrared laser irradiation, these hydrogels accelerated the healing of bacteria-infected CRWI. The therapeutic mechanism involves the regulation of apoptosis-related proteins, including Bax and Bcl-2, effectively inhibiting the apoptotic process. This study highlights the dual-action potential of CMNs and PS@CMNs hydrogels in mitigating radiation damage and promoting wound healing, offering a promising marine biomaterial-based approach for radiation protection and regenerative medicine.
基金：
Natural Science Foun-dation of Shanghai [24ZR1480000]; National Natural Science Foundation of China (NSFC) [82271396]; National Key Research and Development Program of China [2023YFC3107203]; Shanghai Sailing Program [19YF1459000]
第一作者机构：[1]Naval Med Univ, Dept Radiat Med, Coll Naval Med, 800 Xiangyin Rd, Shanghai 200433, Peoples R China
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推荐引用方式(GB/T 7714)：
Zhao Zhemeng,Hu Bin,Zhang Danfeng,et al.Engineering cuttlefish melanin nanoparticles: A dual-action therapy for acute radiation syndrome and combined radiation-wound injuries via regulating Bcl-2 family proteins and caspases in the apoptotic process[J].CHEMICAL ENGINEERING JOURNAL.2025,511:doi:10.1016/j.cej.2025.162108.
APA：
Zhao, Zhemeng,Hu, Bin,Zhang, Danfeng,Cui, Xinyue,Ding, Wen...&Guo, Jiaming.(2025).Engineering cuttlefish melanin nanoparticles: A dual-action therapy for acute radiation syndrome and combined radiation-wound injuries via regulating Bcl-2 family proteins and caspases in the apoptotic process.CHEMICAL ENGINEERING JOURNAL,511,
MLA：
Zhao, Zhemeng,et al."Engineering cuttlefish melanin nanoparticles: A dual-action therapy for acute radiation syndrome and combined radiation-wound injuries via regulating Bcl-2 family proteins and caspases in the apoptotic process".CHEMICAL ENGINEERING JOURNAL 511.(2025)
材料科学