详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

Aqueous humour concentrations of HB-EGF, EGF and VEGF-A and axial length in humans

1| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Beijing Tongren Eye Centre, Beijing Key Laboratory of Intraocular Tumour Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. [2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China. [3]Rothschild Foundation Hospital, Institute Francais de Myopie, Paris, France. [4]Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. [5]Privatpraxis Prof Jonas Und Dr. Panda-Jonas, Heidelberg, Germany. [6]Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China. [7]New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

出处：

DOI：

ISSN：

关键词： axial length axial myopia epidermal growth factor heparin-binding epidermal growth factor myopia myopic macular degeneration vascular endothelial growth factor

摘要：

To investigate relationships between the intraocular concentrations of heparin-binding epidermal growth factor (HB-EGF), epidermal growth factor (EGF) and vascular endothelial growth factor A (VEGF-A) in dependence on axial length in humans.Clinical interventional cohort study.Patients with cataract who underwent routine cataract surgery. Inclusion criterion was the absence of any retinal or optic nerve disease except for myopic macular degeneration (MMD) without myopic choroidal neovascularization.Using a Luminex system, we measured the concentrations of HB-EGF, EGF and VEGF-A in aqueous humour samples taken from patients during cataract surgery.Intracameral concentration of EGF, HB-EGF and VEGF; Axial length.The study included 68 patients (age: 61.1 ± 11 years; range: 44-85 years) with a mean axial length of 27.11 ± 3.11 mm (range: 22.09-35.64 mm). The HB-EGF concentration (mean: 3.17 ± 0.99 pg/mL) increased with longer axial length (β = 0.43; p < 0.001) and was not associated with age (p = 0.10) and intracameral EGF concentration (p = 0.22). The EGF concentration (mean: 0.22 ± 0.12 pg/mL) increased with longer axial length (β = 0.35; p = 0.004) and higher prevalence of advanced MMD (β = 0.35; p = 0.008) and was not associated with age (p = 0.28) and intracameral VEGF-A concentration (p = 0.09). The VEGF-A concentration (mean: 118 ± 150 pg/mL) decreased with longer axial length (β = -0.54; p < 0.001), higher intracameral concentration of HB-EGF (β = -0.26; p = 0.03) and lower MMD prevalence (β = -0.31; p = 0.02) and was not associated with age (p = 0.47) and intracameral EGF concentration (p = 0.09).With the concentrations of HB-EGF and EGF increasing with longer axial length, the study supports a potential role of the EGFR signalling pathway activation in human axial myopia. The inverse relationship between VEGF-A concentration and longer axial length agrees with a protective effect of axial myopia against diabetic retinopathy and age-related macular degeneration.© 2025 The Author(s). Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2025]版：

大类 | 3 区医学

小类 | 2 区眼科学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区眼科学

JCR分区：

出版当年[2023]版：

Q1 OPHTHALMOLOGY

最新[2023]版：

Q1 OPHTHALMOLOGY

影响因子： 3 最新[2023版] 3.3 最新五年平均 3 出版当年[2023版] 3.3 出版当年五年平均 3.4 出版前一年[2022版]

第一作者：

第一作者机构： [1]Beijing Tongren Eye Centre, Beijing Key Laboratory of Intraocular Tumour Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

Aqueous humour concentrations of HB-EGF, EGF and VEGF-A and axial length in humans

文献详情

相关文献