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LncRNA RMG controls liquid-liquid phase separation of MEIS2 to regulate myogenesis

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Yao Yilong[1,2,3] * ; Zhou Rong[4] * ; Yan Chao[1,2,3] * ; Yan Shanying[1,2,3] ; Han Guohao[1,2,3] ; Liu Yanwen[2,3,5] ; Fan Danyang[2,3,5] ; Chen Zhilong[1,2,3] ; Fan Xinhao[2,3,5] ; Chen Yun[2] ; Li Jiaying[6] ; Yang Yalan[1,2,3] ; Tang Zhonglin[1,2,3] ;
机构： [1]Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China [2]Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Foshan 528226, China [3]Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China. [4]Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. [5]Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan 430070, China. [6]Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
出处：
DOI： 10.1016/j.ijbiomac.2025.143309
ISSN：

关键词： Lnc-RMG Myogenesis MEIS2 LLPS

摘要：
Long non-coding RNAs (lncRNAs) regulate liquid-liquid phase separation (LLPS), driving the formation of biomolecular condensates essential for cellular function. However, this regulatory mechanism is yet to be reported in skeletal muscles. In this study, we comprehensively analyzed lncRNAs in skeletal muscle across multiple pig breeds, developmental stages, and tissues. Our analysis identified over 10,000 novel lncRNAs. We found that the lnc-regulator of muscle growth (lnc-RMG) regulates myogenesis by modulating the LLPS of Meis homeobox 2 (MEIS2). Lnc-RMG was specifically expressed in the skeletal muscle, with significantly higher expression in the fetal stage than in the embryonic stage. Notably, lnc-RMG was highly conserved between pigs and humans and exhibits similar biological functions in myogenesis. Furthermore, lnc-RMG knockdown promoted skeletal muscle regeneration. Mechanistically, lnc-RMG produces mature microRNA (miR)-133a-3p, which targets and inhibits MEIS2 expression, thereby inhibiting MEIS2 LLPS. This inhibition promoted the transcription of transforming growth factor-β receptor II (TGFβR2), ultimately regulating myogenesis. Overall, our findings revealed a novel lnc-RMG/miR-133a-3p/MEIS2/TGFβR2 axis that regulated myogenesis through LLPS and provided new insights into the molecular mechanisms that drive muscle development and regeneration. These findings highlight potential therapeutic targets for muscle-related diseases and novel strategies for livestock improvement.Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.

基金：
This work was supported by a grant from the National Natural Science Foundation of China [U23A20229, 32302718, 32172697]; National Key Scientific Research Project [2023YFF1001100]; Chinese Academy of Agricultural Sciences [CAAS-ZDRW202406]. Funding for open access charge: National Natural Science Foundation of China [U23A20229].
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
JCR分区：
出版当年[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China [2]Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Foshan 528226, China [3]Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
共同第一作者：
通讯作者：
通讯机构： [1]Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China [2]Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Foshan 528226, China [3]Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
推荐引用方式(GB/T 7714)：
Yao Yilong,Zhou Rong,Yan Chao,et al.LncRNA RMG controls liquid-liquid phase separation of MEIS2 to regulate myogenesis[J].International Journal Of Biological Macromolecules.2025,310:143309.doi:10.1016/j.ijbiomac.2025.143309.
APA：
Yao Yilong,Zhou Rong,Yan Chao,Yan Shanying,Han Guohao...&Tang Zhonglin.(2025).LncRNA RMG controls liquid-liquid phase separation of MEIS2 to regulate myogenesis.International Journal Of Biological Macromolecules,310,
MLA：
Yao Yilong,et al."LncRNA RMG controls liquid-liquid phase separation of MEIS2 to regulate myogenesis".International Journal Of Biological Macromolecules 310.(2025):143309

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