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Exploration of the shared gene signatures and molecular mechanisms between cardioembolic stroke and ischemic stroke

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机构： [1]Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [2]School of Medicine, Tongji University, Shanghai, China. [3]Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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关键词： cardioembolic stroke ischemic stroke biomarker autophagy neutrophil

摘要：

This study aimed to investigate the shared molecular mechanisms underlying cardioembolic stroke (CS) and ischemic stroke (IS) using integrated bioinformatics analysis.Microarray datasets for the CS (GSE58294, blood samples from CS and controls) and IS (GSE16561, blood from IS and controls; GSE22255, peripheral blood mononuclear cells from IS and matched controls) were acquired from the Gene Expression Omnibus database. Differential expression analysis and weighted gene co-expression network analysis were utilized to identify shared genes between the two diseases. Protein-protein interaction (PPI) network and topology analyses were conducted to identify the core shared genes. Three machine learning algorithms were employed to detect biomarkers from the core shared genes, and the diagnostic value of the hub genes was evaluated by establishing a predictive nomogram. Immune infiltration was evaluated using single-sample gene set enrichment analysis (ssGSEA), and pathways were analyzed with gene set enrichment analysis.There were 125 shared up-regulated genes and 2 shared down-regulated between CS and IS, which were mainly involved in immune inflammatory response-related biological functions. The Maximum Clique Centrality algorithm identified 25 core shared genes in the PPI network constructed using the shared genes. ABCA1, CLEC4E, and IRS2 were identified as biomarkers for both CS and IS and performed well in predicting the onset risk of CS and IS. All three biomarkers were highly expressed in both CS and IS compared to their corresponding controls. These biomarkers significantly correlated with neutrophil infiltration and autophagy activation in both CS and IS. Particularly, all three biomarkers were associated with the activation of neutrophil extracellular trap formation, but only in the IS.ABCA1, CLEC4E, and IRS2 were identified as potential key biomarkers and therapeutic targets for CS and IS. Autophagy and neutrophil infiltration may represent the common mechanisms linking these two diseases.Copyright © 2025 Wang and Liu.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

JCR分区：

出版当年[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 3.3 最新五年平均 2.7 出版当年[2023版] 3.3 出版当年五年平均 3.4 出版前一年[2022版]

第一作者：

第一作者机构： [1]Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [2]School of Medicine, Tongji University, Shanghai, China.

通讯作者：

通讯机构： [2]School of Medicine, Tongji University, Shanghai, China. [3]Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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Exploration of the shared gene signatures and molecular mechanisms between cardioembolic stroke and ischemic stroke

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