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Investigating Shared Diagnostic Genes and Mechanisms Between Metabolic Syndrome and Dry Eye Disease via Integrated Bioinformatics Analysis and In Vivo Validation

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收录情况： ◇ SCIE

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机构： [1]Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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关键词： Metabolic syndrome Dry eye disease Bioinformatics Molecular mechanism

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Recent research has established a bidirectional connection between metabolic syndrome (MetS) and dry eye disease (DED); however, the underlying mechanisms driving their co-occurrence remain poorly understood. This study employed bioinformatics and in vivo validation to investigate the shared diagnostic genes and underlying mechanisms linking MetS and DED. Differential expression analysis using Limma and weighted gene co-expression network analysis (WGCNA) identified 247 shared driver genes from MetS and DED cohorts. Functional enrichment analysis indicated that these genes are associated with immune regulation and inflammatory responses. Key diagnostic genes (Ccl5, Cxcr4, Ccl4, Spp1) were identified via PPI network analysis and validated using a receiver operating characteristic (ROC) curve. The MetS-DED mouse model further demonstrated CXCR4 overexpression in corneal epithelium and liver. These findings elucidate overlapping biomarkers and pathogenic pathways between MetS and DED, providing critical insights for advancing their diagnosis and therapeutic strategies.Copyright © 2025. Published by Elsevier Ltd.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 2 区眼科学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区眼科学

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出版当年[2023]版：

Q1 OPHTHALMOLOGY

最新[2023]版：

Q1 OPHTHALMOLOGY

影响因子： 3 最新[2023版] 3.3 最新五年平均 3 出版当年[2023版] 3.3 出版当年五年平均 3.4 出版前一年[2022版]

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第一作者机构： [1]Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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